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Key Documents

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B6311

Sigma-Aldrich

BTO-1

≥98% (HPLC), solid

Sinónimos:

5-Cyano-7-nitro-2-benzothiazolecarboxamide-3-oxide

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About This Item

Fórmula empírica (notación de Hill):
C9H4N4O4S
Número de CAS:
40647-02-7
Peso molecular:
264.22
MDL number:
MFCD11045282
UNSPSC Code:
12352200
PubChem Substance ID:
329773275
NACRES:
NA.77

assay

≥98% (HPLC)

form

solid

color

tan

solubility

H2O: <2 mL/mL
DMSO: ≥5 mg/mL

storage temp.

2-8°C

SMILES string

NC(=O)c1sc2c(cc(cc2[n+]1[O-])C#N)[N+]([O-])=O

InChI

1S/C9H4N4O4S/c10-3-4-1-5-7(6(2-4)13(16)17)18-9(8(11)14)12(5)15/h1-2H,(H2,11,14)

InChI key

FKRBAXZAJBBIAJ-UHFFFAOYSA-N

Biochem/physiol Actions

BTO-1 is a polo-like kinase (Plk) inhibitor.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Mark E Burkard et al.
PLoS biology, 7(5), e1000111-e1000111 (2009-05-27)
Animal cells initiate cytokinesis in parallel with anaphase onset, when an actomyosin ring assembles and constricts through localized activation of the small GTPase RhoA, giving rise to a cleavage furrow. Furrow formation relies on positional cues provided by anaphase spindle
Campbell McInnes et al.
Nature chemical biology, 2(11), 608-617 (2006-10-10)
Polo-like kinases (Plks) have several functions in mitotic progression and are upregulated in many tumor types. Small-molecule Plk inhibitors would be valuable as tools for studying Plk biology and for developing antitumor agents. Guided by homology modeling of the Plk1
Conrad von Schubert et al.
PLoS biology, 8(9) (2010-10-12)
The protozoan parasite Theileria inhabits the host cell cytoplasm and possesses the unique capacity to transform the cells it infects, inducing continuous proliferation and protection against apoptosis. The transforming schizont is a multinucleated syncytium that resides free in the host
Kristin P Leister et al.
Current chemical genomics, 5, 21-29 (2011-06-07)
Tumor Necrosis Factor-α (TNF-α), a secreted cytokine, plays an important role in inflammatory diseases and immune disorders, and is a potential target for drug development. The traditional assays for detecting TNF-α, enzyme linked immunosorbent assay (ELISA) and radioimmunoassay, are not
Keiko Yata et al.
Molecular cell, 45(3), 371-383 (2012-02-14)
Homologous recombination (HR) plays an important role in the maintenance of genome integrity. HR repairs broken DNA during S and G2 phases of the cell cycle but its regulatory mechanisms remain elusive. Here, we report that Polo-like kinase 1 (Plk1)
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