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B4813

Sigma-Aldrich

BGP-15

≥98% (HPLC)

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About This Item

Fórmula empírica (notación de Hill):
C14H22N4O2· 2HCl
Número de CAS:
66611-37-8
Peso molecular:
351.27
MDL number:
MFCD21603901
UNSPSC Code:
12352200
PubChem Substance ID:
329773244
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

solid

solubility

deionized water: 28 mg/mL

storage temp.

−20°C

SMILES string

Cl.Cl.N\C(=N/OCC(O)CN1CCCCC1)c2cccnc2

InChI

1S/C14H22N4O2.2ClH/c15-14(12-5-4-6-16-9-12)17-20-11-13(19)10-18-7-2-1-3-8-18;;/h4-6,9,13,19H,1-3,7-8,10-11H2,(H2,15,17);2*1H

InChI key

ISGGVCWFTPTHIX-UHFFFAOYSA-N

General description

BGP-15 is a hydroxylamine derivative, which has cytoprotective and neuroprotective properties. It reduces phospho- c-Jun N-terminal kinase (pJNK) and p38 stress signalling. BGP-15 also stimulates non-specific serine/threonine protein kinase (AKT) and insulin-like growth factor 1 receptor (IGFR1) protective signalling. BGP-15 functions as an insulin sensitizer in an olanzapine-induced metabolic disorder. It protects cells against cell death and enhances the expression of heat shock protein (HSP). BGP-15 might be used to treat heart failure (HF) and atrial fibrillation (AF).

Application

BGP-15 has been used to study its influence on proteasomal degradation of missense dystrophins.

Biochem/physiol Actions

BGP-15 is PARP inhibitor, HSP72 activator.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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BGP-15 protects against oxidative stress-or lipopolysaccharide-induced mitochondrial destabilization and reduces mitochondrial production of reactive oxygen species
Sumegi K, et al.
PLoS ONE, 12(1), e0169372-e0169372 (2017)
Disease-proportional proteasomal degradation of missense dystrophins
Talsness DM, et al.
Proceedings of the National Academy of Sciences of the USA, 112(40), 12414-12419 (2015)
BGP-15 prevents the death of neurons in a mouse model of familial dysautonomia
Ohlen SB, et al.
Proceedings of the National Academy of Sciences of the USA, 114(19), 5035-5040 (2017)
Urszula Brykczynska et al.
Cell reports, 30(5), 1627-1643 (2020-02-06)
The innate immune system safeguards the organism from both pathogenic and environmental stressors. Also, physiologic levels of nutrients affect organismal and intra-cellular metabolism and challenge the immune system. In the long term, over-nutrition leads to low-grade systemic inflammation. Here, we
Geeta Sapra et al.
Nature communications, 5, 5705-5705 (2014-12-10)
Heart failure (HF) and atrial fibrillation (AF) share common risk factors, frequently coexist and are associated with high mortality. Treatment of HF with AF represents a major unmet need. Here we show that a small molecule, BGP-15, improves cardiac function

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