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Merck
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AV50490

Sigma-Aldrich

Anti-SHC1 antibody produced in rabbit

affinity isolated antibody

Sinónimos:

Anti-FLJ26504, Anti-SHC, Anti-SHC (Src homology 2 domain containing) transforming protein 1, Anti-SHCA, Anti-p52SHC, Anti-p66, Anti-p66SHC

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

52 kDa

species reactivity

mouse, guinea pig, horse, dog, human, bovine, rat, rabbit

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_892113

UniProt accession no.

P29353

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... SHC1(6464)

Immunogen

Synthetic peptide directed towards the C terminal region of human SHC1

Application

Anti-SHC1 antibody produced in rabbit is suitable for western blotting at a concentration of 1.0μg/ml.

Biochem/physiol Actions

Src homology 2 domain containing) transforming protein 1 (SHC1; SHC; SHCA) gene encodes three isoforms, p66Shc, p52Shc and p46Shc. p52Shc and p46Shc are involved recruitment of Grb2/Sos complex and activation of Ras pathway. p66Shc is involved in regulating the effects of reactive oxygen species and aging.

Sequence

Synthetic peptide located within the following region: AEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQ

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Alessandra Berry et al.
Neuroscience and biobehavioral reviews, 37(5), 790-802 (2013-03-26)
Life expectancy in the last century has greatly increased although, in most industrialized countries, this has been paralleled by an increased incidence of neurodegenerative disorders, in addition to cardiovascular and metabolic pathologies. The p66(Shc) gene has emerged as a novel
Elena De Marchi et al.
Oxidative medicine and cellular longevity, 2013, 564961-564961 (2013-04-23)
Reactive oxygen species (ROS) are a byproduct of the normal metabolism of oxygen and have important roles in cell signalling and homeostasis. An imbalance between ROS production and the cellular antioxidant defence system leads to oxidative stress. Environmental factors and
K S Ravichandran
Oncogene, 20(44), 6322-6330 (2001-10-19)
The adapter protein Shc was initially identified as an SH2 containing proto-oncogene involved in growth factor signaling. Since then a number of studies in multiple systems have implicated a role for Shc in signaling via many different types of receptors
Santosh Kumar et al.
Biochemical and biophysical research communications, 449(4), 496-501 (2014-05-23)
Hypercholesterolemia leads to a prothrombotic phenotype. Platelet hyperactivity associated with hypercholesterolemia has been attributed, in part, to oxidative stress. P66Shc is a well-known determinant of cellular and organismal oxidative stress. However, its role in platelet biology is not known. We
M Halon et al.
Free radical research, 48(11), 1363-1370 (2014-09-02)
Recently, iron and the adaptor protein "p66Shc" have been shown to play an important role in the development of amyotrophic lateral sclerosis (ALS) in rats. We hypothesized that changes in muscle p66Shc activity and iron metabolism would appear before visible
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