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A3418

Sigma-Aldrich

Anti-α1-Acid Glycoprotein antibody produced in goat

whole antiserum

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About This Item

MDL number:
MFCD00162118
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

conjugate

unconjugated

antibody form

whole antiserum

antibody product type

primary antibodies

clone

polyclonal

mol wt

antigen 40.8 kDa (sedimentation velocity and diffusion studies)

contains

15 mM sodium azide

species reactivity

human

technique(s)

quantitative precipitin assay: 1.5 mg/mL

UniProt accession no.

P02763

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ORM1(5004)

General description

α-1 acid glycoprotein is a protein at 43kDa secreted mainly from the liver during acute phase reaction. Its expression is induced by cytokines and corticosteroids.
Alpha-1-acid glycoprotein (AGP) is also known as orosomucoid (ORM). It is a 41-43 kDa glycoprotein. It is one of the important acute phase proteins found in humans, rats, mice and other species. This immunosuppressive glycoprotein is composed of two isoforms, such as ORM1 and ORM2.
Goat Anti-α1-Acid Glycoprotein antibody is immunospecific for human α1-acid glycoprotein by immunoelectrophoresis versus human serum and α1-acid glycoprotein.

Immunogen

purified human α1-acid glycoprotein

Application

Goat Anti-α1-Acid Glycoprotein antibody can be used for quantitative precipitin assays at 1.5mg/ml.

Biochem/physiol Actions

Abberations of orosomucoid 1 (ORM1) is linked with the pharmacokinetics of telmisartan. This plasma protein participates in the binding and transport of several drugs.

Physical form

Supplied as a liquid containing 15mM sodium azide as preservative.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Referencia del producto
Descripción
Precios

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H312,H412

pcodes

P280

Hazard Classifications

Acute Tox. 4 Dermal - Aquatic Chronic 3

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 3

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Effect of alpha-1-acid glycoprotein binding on pharmacokinetics and pharmacodynamics
Huang Z, et al.
Current Drug Metabolism, 14(2), 226-238 (2013)
P A Charlwood et al.
Biochimica et biophysica acta, 453(1), 81-92 (1976-11-26)
We have isolated from the plasma of man, rabbit, pig, rat and chicken alpha 1-acid glycoproteins that show a single band on polyacrylamide gel electrophoresis and a single arc in immunodiffusion. Amino acid and carbohydrate compositions are presented. The human
K Kostner et al.
Clinica chimica acta; international journal of clinical chemistry, 304(1-2), 29-37 (2001-02-13)
The atherogenic lipoprotein Lp(a) consists of an LDL-like core and apo(a), linked to apoB via a thiol bridge. Apo(a) fragments ranging in size from 60 to 220 kDa are excreted into urine and the excretion rate correlates significantly with the
Polymorphism of ORM1 Is Associated with the Pharmacokinetics of Telmisartan
Chen WQ, et al.
PLoS ONE, 8(8) (2013)
Polymorphism of ORM1 Is Associated with the Pharmacokinetics of Telmisartan
Chen WQ, et al.
Testing, 8(8) (2013)
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