Saltar al contenido
Merck
Todas las fotos(3)

Key Documents

View All Documentation

A3233

Sigma-Aldrich

L-Arginase from bovine liver

Protein ≥70 % by biuret, powder

Sinónimos:

L-Arginine amidinase, L-Arginine amidino-hydrolase

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(3)

About This Item

Número de CAS:
9000-96-8
Comisión internacional de enzimas:
3.5.3.1 (BRENDA, IUBMB)
EC Number:
232-570-3
MDL number:
MFCD00081368
UNSPSC Code:
12352204
NACRES:
NA.77

biological source

bovine liver

form

powder

specific activity

≥100 units/mg protein

composition

Protein, ≥70% biuret

UniProt accession no.

Q58DL1

shipped in

dry ice

storage temp.

−20°C

Gene Information

cow ... ARG2(518752)

¿Está buscando productos similares? Visita Guía de comparación de productos

General description

L-arginase is also called as L-arginine amidinohydrolase. It exists in two forms, such as arginase-1 and arginase-2. Arginase-1 is present in liver cells and arginase-2 is seen usually in extrahepatic tissues like, kidney, brain, skeletal muscle, small intestine and the lactating mammary gland. Arginase -2 is mapped to human chromosome 14q24.1−24.3.

Biochem/physiol Actions

L-Arginase is the major degradative enzyme for arginine; converts arginine to ornithine; deficiency is associated with spasticity and motor dysfunction.
L-arginase hydrolyze L-arginine into L-ornithine and urea, which is the last step of the urea cycle in the liver of ureotelic species. Arginase plays a major role in the mammalian immune system and the enzyme participates in several aspects of inflammation.

Unit Definition

One unit will cause the hydrolysis of 1.0 μmole of L-arginine per minute at pH 9.5 and 37 °C.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H334

Hazard Classifications

Resp. Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

L-Arginase: a Medically Important Enzyme
Kumar K and Verma N
Research Journal of Pharmacy and Technology, 6(12), 1430-1430 (2013)
Arginase: an emerging key player in the mammalian immune system
Munder M
British Journal of Pharmacology, 158(3), 638-651 (2009)
Abhishek Srivastava et al.
Biochemistry, 52(3), 508-519 (2012-12-29)
Urea producing bimetallic arginases are essential for the synthesis of polyamine, DNA, and RNA. Despite conservation of the signature motifs in all arginases, a nonconserved ¹⁵³ESEEKAWQKLCSL¹⁶⁵ motif is found in the Helicobacter pylori enzyme, whose role is yet unknown. Using
James W Wells et al.
PloS one, 8(1), e54464-e54464 (2013-02-01)
Rapidly growing tumor cells require a nutrient-rich environment in order to thrive, therefore, restricting access to certain key amino acids, such as arginine, often results in the death of malignant cells, which frequently display defective cell cycle check-point control. Healthy
Shelley B Weisser et al.
Methods in molecular biology (Clifton, N.J.), 946, 225-239 (2012-11-28)
Macrophages play a key role in the innate immune response and help to direct the acquired immune response. Early in the innate immune response, they produce reactive oxygen species and pro-inflammatory cytokines and chemokines to drive inflammation and are referred
Ver todos los artículos relacionados

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico