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89870

Sigma-Aldrich

Toluene 2,4-diisocyanate

purum, suitable for electron microscopy, ≥98.0% (GC)

Sinónimos:

2,4-Diisocyanatotoluene, 4-Methyl-m-phenylene diisocyanate, Tolylene 2,4-diisocyanate

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About This Item

Fórmula empírica (notación de Hill):
C9H6N2O2
Número de CAS:
584-84-9
Peso molecular:
174.16
Beilstein/REAXYS Number:
744602
EC Number:
209-544-5
MDL number:
MFCD00002011
UNSPSC Code:
12352200
PubChem Substance ID:
57653363
NACRES:
NA.25

grade

purum

Quality Level

200

assay

≥98.0% (GC)

form

liquid

technique(s)

electron microscopy: suitable

refractive index

n20/D 1.567

bp

124-126 °C/18 mmHg (lit.)
251 °C (lit.)

mp

19.5-21.5 °C (lit.)

density

1.21 g/mL at 20 °C
1.22 g/mL at 20 °C (lit.)

SMILES string

Cc1ccc(cc1N=C=O)N=C=O

InChI

1S/C9H6N2O2/c1-7-2-3-8(10-5-12)4-9(7)11-6-13/h2-4H,1H3

InChI key

DVKJHBMWWAPEIU-UHFFFAOYSA-N

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Application

Toluene 2,4-diisocyanate is used to study it occupational hazards (asthma, dermatitis) and mechanisms of action. Reagent for covalent protein crosslinking; For the immobilization of antibodies to a plastic surface for RIA

Other Notes

Reagent for covalent protein crosslinking; For the immobilization of antibodies to a plastic surface for RIA

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 2

flash_point_f

269.6 °F - closed cup

flash_point_c

132 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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T Saito et al.
Clinica chimica acta; international journal of clinical chemistry, 133(3), 301-310 (1983-10-14)
A novel procedure to fix antibody on a plastic surface was developed, using a polystyrene tube treated with 0.5% toluene 2,4-diisocyanate (TC) dissolved in carbon tetrachloride. Using 125I-labelled IgG, we found that the rate of immobilization of IgG was significantly
[57] Bifunctional reagents.
F Wold
Methods in enzymology, 25, 623-651 (1972-01-01)
Rahul Purwar et al.
Experimental dermatology, 20(9), 709-714 (2011-05-17)
Keratinocytes synthesize complement component 3 (C3) constitutively, and increased expression of C3 has been described during skin inflammation. In this study, we investigated the role of C3 in T cell-mediated allergic contact dermatitis, which is a clinical manifestation of contact
Olov Collste et al.
Journal of cardiac failure, 20(12), 968-972 (2014-10-01)
Our objective was to investigate whether dobutamine stress echocardiography (DSE) could induce abnormal cardiac function in takotsubo stress cardiomyopathy (TSC) patients in a stable condition after the acute attack. This was a case-control study and a substudy of the Stockholm
Tatiana Kuznetsova et al.
American journal of hypertension, 28(4), 535-545 (2014-09-23)
The cardio-renal interaction occurs via hemodynamic and humoral factors. Noninvasive assessment of renal hemodynamics is currently possible by assessment of renal resistive index (RRI) derived from intrarenal Doppler arterial waveforms as ((peak systolic velocity - end-diastolic velocity)/peak systolic velocity). Limited
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