PHR1379

Atropine Sulfate

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinónimos: Atropine sulfate salt monohydrate, α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, Tropine tropate
• Fórmula lineal: (C₁₇H₂₃NO₃)₂ · H₂SO₄ · H₂O
• Número de CAS: 5908-99-6
• Peso molecular: 694.83
• Beilstein/REAXYS Number: 6109275
• EC Number: 200-235-0
• MDL number: MFCD00074815
• UNSPSC Code: 41116107
• PubChem Substance ID: 329823356
• NACRES: NA.24

Propiedades

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• agency: traceable to BP 23; traceable to Ph. Eur. A1400000; traceable to USP 1045009
• API family: atropine
• CofA: current certificate can be downloaded
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• mp: 189-192 °C (A) (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: O.OS(O)(=O)=O.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3.CN4[C@H]5CC[C@@H]4C[C@@H](C5)OC(=O)C(CO)c6ccccc6
• InChI: 1S/2C17H23NO3.H2O4S.H2O/c2*1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4;/h2*2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4);1H2/t2*13-,14+,15+,16?;;
• InChI key: JPKKQJKQTPNWTR-CHYDPLAESA-N
• Gene Information: human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131)

Descripción

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Atropine Sulfate is an alkaloid extracted from belladonna herb. It is a cholinergic drug, administered as an anti-arrhythmic medicine.

Application

Atropine Sulfate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by electrophoresis and chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC4087 in the slot below. This is an example certificate only and may not be the lot that you receive.

Información de seguridad

• pictograms: GHS06
• signalword: Danger
• hcodes: H300 + H330
• pcodes: P260 - P264 - P271 - P284 - P304 + P340 + P310 - P403 + P233
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• Storage Class: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable