PHR1331
Metformin Related Compound A
Pharmaceutical Secondary Standard; Certified Reference Material
Sinónimos:
Dicyandiamide, Cyanoguanidine, Dicyanodiamide
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About This Item
Fórmula lineal:
NH2C(=NH)NHCN
Número de CAS:
Peso molecular:
84.08
Beilstein/REAXYS Number:
605637
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
Productos recomendados
grade
certified reference material
pharmaceutical secondary standard
Quality Level
agency
traceable to USP 1396310
API family
metformin
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
mp
208-211 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
SMILES string
NC(=N)NC#N
InChI
1S/C2H4N4/c3-1-6-2(4)5/h(H4,4,5,6)
InChI key
QGBSISYHAICWAH-UHFFFAOYSA-N
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General description
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
It is an impurity of the widely used antidiabetic drug, metformin, that belongs to the biguanide class of compounds.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
It is an impurity of the widely used antidiabetic drug, metformin, that belongs to the biguanide class of compounds.
Application
This pharmaceutical secondary standard can also be used as follows:
- Separation and estimation of metformin along with other antidiabetics from meglitinides class in the presence of metformin impurity cyanoguanidine using a liquid chromatography method in pharmaceutical formulations
- Development of a reversed phase-high performance liquid chromatographic (RP-HPLC) method combined with a UV-diode array detector (PDA) for the impurity analysis of combined dosage tablet of metformin hydrochloride and teneligliptin hydrobromide hydrate
- Estimation of empagliflozin, linagliptin, along with metformin and its related impurities cyanoguanidine and melamine using HPLC-DAD and high-performance thin layer chromatography (HPTLC) methods in their combined tablets
- Development and validation of a stability indicating capillary zone electrophoresis (CZE) method for the quantification of metformin and its major impurity in pharmaceutical formulation
- Simultaneous determination of vildagliptin, metformin, and metformin-related compounds (A, B, and C) in tablets using a high-performance liquid chromatography-tandem mass spectrometry method (HPLC-MS/MS)
Analysis Note
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
Footnote
To see an example of a Certificate of Analysis for this material enter LRAA0834 in the slot below. This is an example certificate only and may not be the lot that you receive.
Related product
Referencia del producto
Descripción
Precios
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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