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Merck

P4722

Sigma-Aldrich

Pyridoxine hydrochloride

meets USP testing specifications

Sinónimos:

Adermine hydrochloride, PN HCl, Pyridoxol hydrochloride, Vitamin B6 hydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C8H11NO3 · HCl
Número de CAS:
Peso molecular:
205.64
Beilstein/REAXYS Number:
3632435
EC Number:
MDL number:
UNSPSC Code:
12352205
eCl@ss:
34058008
PubChem Substance ID:
NACRES:
NA.21

biological source

synthetic (organic)

Quality Level

agency

USP/NF
meets USP testing specifications

assay

98.0-102.0% dry basis

form

powder

color

white

mp

214-215 °C (lit.)

application(s)

pharmaceutical (small molecule)

SMILES string

Cl[H].Cc1ncc(CO)c(CO)c1O

InChI

1S/C8H11NO3.ClH/c1-5-8(12)7(4-11)6(3-10)2-9-5;/h2,10-12H,3-4H2,1H3;1H

InChI key

ZUFQODAHGAHPFQ-UHFFFAOYSA-N

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General description

Vitamin B group is water-soluble and exists in six forms namely the pyridoxal, pyridoxine, pyridoxamine, pyridoxamine 5′-phosphate, pyridoxine 5′-phosphate and pyridoxal 5′-phosphate. The food sources of vitamin B6 include grains, nuts, fruits, vegetables and meat.

Application

Pyridoxine hydrochloride has been used to test its neuroprotective functionality in traumatic brain injury (TBI) rats. It has also been used as a reference standard to quantify vitamin B6 in feed and digesta samples using high-performance liquid chromatography(HPLC).

Biochem/physiol Actions

Pyridoxine plays a key role in metabolism both carbohydrates and amino acids. It supports brain development and its deficiency levels may lead to depletion of γ-aminobutyric acid (GABA) levels. Pyridoxine catalyzes the neurotransmitter biosynthesis like dopamine and serotonin. Pyridoxine in excess or deficient may lead to neuropathy.

pictograms

Corrosion

signalword

Danger

hcodes

Hazard Classifications

Eye Dam. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Visite la Librería de documentos

Nutritional neuropathies
Hammond N, et al.
Neurologic Clinics, 31(2), 477-477 (2013)
B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin
Calderon-Ospina CA, et al.
CNS Neuroscience & Therapeutics (2019)
Pyridoxine administration improves behavioral and anatomical outcome after unilateral contusion injury in the rat
Kuypers NJ and Hoane MR
Journal of Neurotrauma, 27(7), 1275-1282 (2010)
Effects of forage family on apparent ruminal synthesis of B vitamins in lactating dairy cows
Castagnino DS, et al.
Journal of Dairy Science, 99(3), 1884-1894 (2016)
Determination of vitamin B6 (pyridoxine) in pharmaceutical preparations by cyclic voltammetry at a copper (II) hexacyanoferrate (III) modified carbon paste electrode
Teixeira MFS, et al.
Journal of the Brazilian Chemical Society, 14(2), 316-321 (2003)

Artículos

This page segues to comprehensive insights on how Vitamin B6, Pyridoxal and Pyridoxine affect the performance of serum-free, protein-free cell culture systems used for biomanufacturing heterologous proteins including monoclonal antibodies. The page introduces the in vitro chemistry and biochemistry of pyridoxal, pyridoxine.

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