M3761

Metronidazole

analytical standard

• Sinónimos: 2-Methyl-5-nitroimidazole-1-ethanol
• Fórmula empírica (notación de Hill): C₆H₉N₃O₃
• Número de CAS: 443-48-1
• Peso molecular: 171.15
• Beilstein/REAXYS Number: 611683
• EC Number: 207-136-1
• MDL number: MFCD00009750
• UNSPSC Code: 41116107
• PubChem Substance ID: 329817979
• NACRES: NA.24

Propiedades

• grade: analytical standard
• Quality Level: 100
• form: crystalline
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• mp: 159-161 °C (lit.)
• antibiotic activity spectrum: Gram-negative bacteria; parasites
• application(s): forensics and toxicology; pharmaceutical (small molecule)
• format: neat
• mode of action: DNA synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: CC1=NC=C([N+]([O-])=O)N1CCO
• InChI: 1S/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3
• InChI key: VAOCPAMSLUNLGC-UHFFFAOYSA-N

Descripción

General description

Metronidazole is a nitroimidazole drug, used particularly against infections caused by anaerobic bacteria and protozoa in humans and domestic animals.

Application

The analytical standard can be used as follows:

• Cyclic voltametric determination of metronidazole at carbon paste electrode (CPE) in three different brands of metronidazole tablets
• Simultaneous determination of metronidazole, diloxanide, spiramycin, and cliquinol in pharmaceutical dosage forms by reversed-phase high-performance liquid chromatography coupled to photodiode array detector (RP-HPLC-DAD)
• Development of an electrochemical sensor based on polydopamine/carboxylic multi-walled carbon nano-tubes (MWCNTs-COOH) nanocomposites for the determination of metronidazole
• Liquid chromatography–ion trap mass spectrometry (LC-MS/MS based analysis of metronidazole in water, sediment, and fish tissue samples
• Determination of metronidazole using an electrochemical sensor based on multi-walled carbon nanotubes (MWCNTs) and chitosan-nickel complexes (CTS-Ni) in tablets, human urine, and serum samples

Other Notes

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Información de seguridad

• pictograms: GHS08
• signalword: Danger
• hcodes: H340,H350,H373
• pcodes: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Carc. 1B - Muta. 1B - STOT RE 2
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves