C2100000

Colecalciferol

European Pharmacopoeia (EP) Reference Standard

• Sinónimos: (+)-Vitamina D₃, 7-deshidrocolesterol activado, Activado, 7-deshidrocolesterol, Calciol
• Fórmula empírica (notación de Hill): C₂₇H₄₄O
• Número de CAS: 67-97-0
• Peso molecular: 384.64
• Beilstein/REAXYS Number: 2339331
• MDL number: MFCD00078131
• UNSPSC Code: 41116107
• PubChem Substance ID: 329774925
• NACRES: NA.24

Propiedades

• biological source: synthetic
• grade: pharmaceutical primary standard
• agency: EP
• API family: cholecalciferol
• form: solid
• manufacturer/tradename: EDQM
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• mp: 83-86 °C (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: −20°C
• SMILES string: CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CCC/2)([H])C2=C\C=C(C[C@@H](O)CC3)/C3=C
• InChI: 1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
• InChI key: QYSXJUFSXHHAJI-YRZJJWOYSA-N
• Gene Information: human ... VDR(7421)

Descripción

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Cholecalciferol is a fat soluble vitamin, found commercially in vitamin supplements and rodenticides. It can be directly produced on exposure to sunlight or through normal dietary intake.

Application

This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

La Vitamina D actúa a través de un receptor que forma parte de la superfamilia del factor de transcripción dependiente del ligando. Modula la proliferación y diferenciación de las células normales y cancerosas. Tiene efectos contrarios a la proliferación y desarrollo de metástasis en células de cáncer de mama, colon y próstata. Receptores activados de vitamina D en el intestino y los huesos mantienen la absorción de calcio y la homeostasis.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Información de seguridad

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H300 + H310 + H330 - H372
• pcodes: P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P314
• Hazard Classifications: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - STOT RE 1 Oral
• Storage Class: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable