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Merck

68527

Supelco

Harpagoside

analytical standard

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About This Item

Fórmula empírica (notación de Hill):
C24H30O11
Número de CAS:
Peso molecular:
494.49
EC Number:
MDL number:
UNSPSC Code:
85151701
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

assay

≥95.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

SMILES string

C[C@@]1(C[C@@H](O)[C@]2(O)C=CO[C@@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@H]12)OC(=O)\C=C\c4ccccc4

InChI

1S/C24H30O11/c1-23(35-16(27)8-7-13-5-3-2-4-6-13)11-15(26)24(31)9-10-32-22(20(23)24)34-21-19(30)18(29)17(28)14(12-25)33-21/h2-10,14-15,17-22,25-26,28-31H,11-12H2,1H3/b8-7+/t14-,15-,17-,18+,19-,20-,21+,22+,23+,24-/m1/s1

InChI key

KVRQGMOSZKPBNS-FMHLWDFHSA-N

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General description

Harpagoside, a naturally occurring iridoid glycoside, is the main bioactive component of medicinal plants like Radix Scrophulariae, Scrophularia ningpoensis, Scrophularia buergeriana and Harpagophytum procumbens. It can exhibit a wide range of biological and pharmacological properties and hence used in the treatment of ailments like pharyngalgia, arthritis, rheumatism, tussis and constipation.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Certificados de análisis (COA)

Lot/Batch Number

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Simultaneous determination of harpagoside and cinnamic acid in rat plasma by high-performance liquid chromatography: application to a pharmacokinetic study
Li P, et al.
Analytical and Bioanalytical Chemistry, 389, 2259-2264 (2007)
Harpagoside: from Kalahari Desert to pharmacy shelf
Georgiev.IM, et al.
Phytochemistry, 92, 8-15 (2013)
Steffen Wagner et al.
Journal of pharmaceutical and biomedical analysis, 48(3), 587-591 (2008-07-08)
Preparations of Harpagophytum procumbens and of Salix species are successfully used for the treatment of degenerative rheumatism and painful arthrosis. For the quality control of both drugs, rapid methods of quantification are desirable. Here we report the development of two
Xiaoyu Sun et al.
Journal of neurochemistry, 120(6), 1072-1083 (2011-12-24)
Parkinson's disease is a chronic neurodegenerative movement disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. New therapeutic approaches aiming at delaying or reversing the neurodegenerative process are under active investigations. In this work, we
Eun Ju Jeong et al.
European journal of pharmacology, 588(1), 78-84 (2008-05-09)
The cognitive-enhancing activities of E-harpagoside and 8-O-E-p-methoxycinnamoylharpagide (MCA-Hg) isolated from Scrophularia buergeriana were evaluated in scopolamine-induced amnesic mice by the Morris water maze and by passive avoidance tests. E-harpagoside and MCA-Hg significantly improved the impairment of reference memory induced by

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