33454
Potassium clavulanate
VETRANAL®, analytical standard
Sinónimos:
Clavulanate potassium
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About This Item
Fórmula empírica (notación de Hill):
C8H8NO5K
Número de CAS:
Peso molecular:
237.25
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
Productos recomendados
grade
analytical standard
Quality Level
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
agriculture
clinical
environmental
forensics and toxicology
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
SMILES string
[K+].[H][C@@]12CC(=O)N1[C@@H](C([O-])=O)C(\O2)=C\CO
InChI
1S/C8H9NO5.K/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4;/h1,6-7,10H,2-3H2,(H,12,13);/q;+1/p-1/b4-1-;/t6-,7-;/m1./s1
InChI key
ABVRVIZBZKUTMK-JSYANWSFSA-M
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General description
Potassium clavulanate is an oxapenam derivative and belongs to the group of β-lactamase inhibitors. It is used in combination with the penicillin group of antibiotics to give them resistance to β-lactamase.
Application
The analytical standard can be used as follows:
- Simultaneous analysis of amoxicillin and clavulanate potassium in pharmaceutical formulations by capillary electrophoresis (CE) combined with capacitively coupled contactless conductivity detection (C4D)
- Development of a stability-indicating high-performance liquid chromatographic (HPLC) method combined with mass spectrometry (MS) to measure amoxicillin, clavulanate potassium, and their impurities in their combined dosage forms
- Residue analysis of potassium clavulanate and amoxicillin trihydrate by a UV spectrophotometric method in their bulk, combined tablet formulations, and human urine samples
- HPLC method-based determination of meropenem and potassium clavulanate in the presence of their degradation impurities in intravenous solutions in combination with a diode array detector (DAD)
- Determination of amoxicillin and clavulanic acid by capillary zone electrophoresis (CZE) in their combined commercial formulations
Biochem/physiol Actions
β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.
Other Notes
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Flam. Sol. 2 - Resp. Sens. 1 - Self-heat. 2 - Skin Sens. 1
supp_hazards
Storage Class
4.2 - Pyrophoric and self-heating hazardous materials
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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The global emergence and spread of extended-spectrum beta-lactamases (ESBLs) producing Enterobacteriaceae have been threatening the ability to treat an infection. Hence, this study aimed to determine the prevalence of ESBL-producing and multi-drug resistance (MDR) Enterobacteriaceae (ESBLs-E) from different clinical specimens
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B R Smith et al.
Drug intelligence & clinical pharmacy, 19(6), 415-420 (1985-06-01)
Potassium clavulanate is a novel beta-lactamase inhibitor, which, in combination, expands the spectrum of amoxicillin to include many amoxicillin-resistant organisms. Potassium clavulanate is excreted 30-50 percent unchanged renally and its plasma time-course parallels that of amoxicillin. Several studies suggest that
Ximena Gonzalo et al.
The Journal of antimicrobial chemotherapy, 68(2), 366-369 (2012-10-17)
To: (i) assess if amoxicillin/clavulanate is a useful option for the management of multidrug-resistant/extensively drug-resistant tuberculosis (MDR/XDR-TB); (ii) assess if meropenem/clavulanate is active against Mycobacterium tuberculosis at concentrations achievable in vivo; and (iii) determine whether there was inhibition of meropenem/clavulanate
Oriol Mitjà et al.
The American journal of tropical medicine and hygiene, 86(6), 1043-1045 (2012-06-06)
We report the first documented case of a mycetoma caused by Nocardia yamanashiensis after the initial description of this species. The 16S-rRNA gene sequence analysis was used to identify the novel species, which showed a similarity of 99.9% to the
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