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Merck
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Key Documents

MABX1901

Sigma-Aldrich

Anti-human IgG (1mg) KC

from mouse

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

antibody form

purified antibody

antibody product type

secondary antibodies

clone

monoclonal

species reactivity

human

technique(s)

ELISA: suitable
immunodiffusion: suitable

isotype

IgG2b

General description

Secondary antibody specific for Human Immunoglobulin G
Immunoglobulin G (IgG), an immunoglobulin isotype, is the most abundant protein in human serum and constitutes 10-20% of plasma protein. It is composed of glycoproteins comprising 82-96% of proteins and 4-18% of carbohydrates. IgG is further classified into IgG1, IgG2, IgG3, and IgG4 subclasses. IgG consists of four polypeptide chains, with two heavy chains (γ chains) and two light chains (κ or λ chains), which are linked by inter-chain disulfide bonds. It is secreted by B lymphocytes and found in extracellular fluids and blood.

Specificity

Specific for Human IgG. No cross reactivity with human IgA, IgD, IgE or IgE.

Immunogen

corresponding to Human Serum IgG.

Application

Detect Human Serum IgG using this mouse monoclonal Anti-human IgG (1mg) KC, Cat. No. MABX1901-1KC, validated for use in Lateral Flow Assay and ELISA.

Biochem/physiol Actions

Immunoglobulin G (IgG) primarily contributes to the humoral immune response by neutralizing pathogens such as bacteria, viruses, and protect cells from their toxic substances. IgG is the only isotype transferred to the fetus across the placenta and is vital for immune response of the neonate. Alterations in IgG fragment crystallizable (Fc)-glycosylation are associated with various diseases including rheumatoid arthritis and tuberculosis.

Quality

Tested

Physical form

Format: Purified

Other Notes

Concentration: Please refer to lot specific datasheet.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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The N-glycosylation of mouse immunoglobulin G (IgG)-fragment crystallizable differs between IgG subclasses and strains.
de Haan N, et al.
Frontiers in immunology, 8, 608-608 (2017)
Placental transfer of IgG subclasses in a Japanese population.
Hashira S, et al.
Pediatrics International, 42(4) (2000)
Gestur Vidarsson et al.
Frontiers in immunology, 5, 520-520 (2014-11-05)
Of the five immunoglobulin isotypes, immunoglobulin G (IgG) is most abundant in human serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ in their constant region, particularly in their hinges and upper CH2 domains. These

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Anti-Human Antibodies for COVID-19 (SARS-CoV-2) Immunoglobulin Detection Research

Antibody-based serology tests are useful in identifying subjects with an adaptive immune response to the SARS-CoV-2 virus. Anti-human immunoglobulin antibodies allow for quick and simple, yet reliable assays with easy readouts and can also be adapted for high-throughput screening.

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

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