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Merck
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Key Documents

MABT61

Sigma-Aldrich

Anti-Nectin-1/PVRL1 (CD111) Antibody, clone R1.302

clone R1.302.12, from mouse

Sinónimos:

poliovirus receptor-related 1 (herpesvirus entry mediator C), nectin-1, poliovirus receptor-related protein 1, poliovirus receptor-like 1, nectin 1, ectodermal dysplasia 4 (Margarita Island type), Herpesvirus entry mediator C, Herpes virus entry mediator

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

R1.302.12, monoclonal

species reactivity

human

technique(s)

flow cytometry: suitable
immunofluorescence: suitable

isotype

IgG1κ

NCBI accession no.

NP_002846

UniProt accession no.

Q15223

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... PVRL1(5818)

General description

Nectin-1, also known as poliovirus receptor-related protein 1 (PRR1 or PVRL1) or CD111, is an immunoglobulin-like transmembrane cell adhesion protein that also seems to play a role in neural tube formation, with N-cadherin. Nectins are known for being the receptors for the herpes simplex virus. Nectin-1 is connected with the actin cytoskeleton through afadin inside the cell. It is predominantly found in human placenta although in mice, expression is wide-ranging. Nectin-1 seems to adhere primarily to cells expressing nectin-4 and vice versa.

Immunogen

Human CD111 transfected NIH/3T3 cells

Application

Immunofluorescence Analysis: A previous lot was used by an independent laboratory in IF (Cocchi, F., et al. (1998). Journal of Virology. 72(12):9992–10002).
This Anti-Nectin-1/PVRL1 (CD111) Antibody, clone R1.302 is validated for use in FC, IF for the detection of Nectin-1/PVRL1 (CD111).

Quality

Evaluated by Flow Cytometry in human TF-1 cells.

Flow Cytometry Analysis: 0.25 µg of this antibody detected Nectin-1/PVRL1 in human TF-1 cells.

Target description

57 kDa calculated

Physical form

Format: Purified

Analysis Note

Control
Human TF-1 cells

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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The V domain of herpesvirus Ig-like receptor (HIgR) contains a major functional region in herpes simplex virus-1 entry into cells and interacts physically with the viral glycoprotein D.
Cocchi, F; Lopez, M; Menotti, L; Aoubala, M; Dubreuil, P; Campadelli-Fiume, G
Proceedings of the National Academy of Sciences of the USA null
The ectodomain of a novel member of the immunoglobulin subfamily related to the poliovirus receptor has the attributes of a bona fide receptor for herpes simplex virus types 1 and 2 in human cells.
Cocchi, F; Menotti, L; Mirandola, P; Lopez, M; Campadelli-Fiume, G
Journal of virology null
Kristin L M Boylan et al.
Oncotarget, 8(6), 9717-9738 (2016-12-31)
The cell adhesion molecule Nectin-4 is overexpressed in epithelial cancers, including ovarian cancer. The objective of this study was to determine the biological significance of Nectin-4 in the adhesion, aggregation, migration, and proliferation of ovarian cancer cells. Nectin-4 and its

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