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Key Documents

MABE1041

Sigma-Aldrich

Anti-Pax-9 Antibody, clone 7C2 (P9C23)

clone 7C2 (P9C23), from rat

Sinónimos:

Paired box protein Pax-9, Pax-9

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.43

biological source

rat

Quality Level

antibody form

purified antibody

antibody product type

primary antibodies

clone

7C2 (P9C23), monoclonal

species reactivity

human, mouse

technique(s)

immunohistochemistry: suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... PAX9(5083)

General description

Paired box protein Pax-9 (UniProt P47242; also known as Paired box gene 9) is encoded by the Pax9 gene (Gene ID 18511) in murine species. Pax9 belongs to a family of nine transcription factors (Pax1-9) characterized by the presence of a DNA-binding ‘paired’-domain. Pax family transcription factors regulate the morphogenesis of a wide range of organs and are key factors for the development of mammalian sensory organs such as the eye (Pax6, Pax2), nose (Pax6), ears (Pax2, Pax8), and the endoderm-derived taste papillae (Pax9). In addition, Pax9 expression in the normal epithelium of the adult human oesophagus is reported to be either lost or significantly reduced in the majority of invasive carcinomas and epithelial dysplasias (precancerous lesions). The drop in the percentage of Pax9-positive cells in the epithelium decreases with increasing malignancy of the epithelial lesion.

Immunogen

MBP-tagged recombinant protein corresponding to the C-terminal region of mouse Pax-9.

Application

Anti-Pax-9 Antibody, clone 7C2 (P9C23), Cat. No. MABE1041, is a highly specific rat monoclonal antibody, that targets Pax9 and has been tested in Western Blotting.
Western Blotting Analysis: 1.0 µg/mL from a representative lot detected Pax-9 in 10 µg of HepG2 cell lysate.
Western Blotting Analysis: A representative lot detected Pax-9 in mouse and human oesophagus tissue lysate (Gerber, J.K., et al. (2002). J Pathol. 197(3):293-297).
Immunohistochemistry Analysis: A representative lot detected Pax-9 in mouse and human oesophagus tissue sections (Gerber, J.K., et al. (2002). J Pathol. 197(3):293-297).

Quality

Evaluated by Western Blotting in MOLT 4 cell lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected Pax-9 in 10 µg of MOLT 4 cell lysate.

Target description

~36 kDa observed

Physical form

Format: Purified

Other Notes

Concentration: Please refer to lot specific datasheet.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

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Josef-Karl Gerber et al.
The Journal of pathology, 197(3), 293-297 (2002-07-13)
Pax genes encode a family of transcription factors that play key roles in embryonic development. Whereas the functions of Pax genes in the adult organism are largely unknown, upregulated Pax gene expression has been implicated in tumourigenesis. In this study

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