MAB4150

Anti-MRP2 Antibody, CT, clone M2 III-6

culture supernatant, clone M2 III-6, Chemicon^®

• Sinónimos: cMOAT
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• biological source: mouse
• Quality Level: 300
• antibody form: culture supernatant
• antibody product type: primary antibodies
• clone: M2 III-6, monoclonal
• species reactivity: human
• manufacturer/tradename: Chemicon^®
• technique(s): immunocytochemistry: suitable; immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; western blot: suitable
• isotype: IgG2a
• NCBI accession no.: NM_000392.2
• UniProt accession no.: Q92887
• shipped in: wet ice
• Gene Information: human ... ABCC2(1244)

Descripción

Specificity

This antibody reacts with an internal epitope of MRP2, a 190-200 kDa transmembrane protein previously known as the canalicular multi-organic anion transporter (cMOAT). MRP2 is a member of the MRP family of multidrug resistance related proteins, and MRP2 over expression has been observed in a subset of cisplatin resistant cell lines. This antibody does not cross-react with the human MDR1, MRP1, MRP3 or MRP5 gene products.

Immunogen

Bacterial fusion protein of MRP2 containing the 202-aa C-terminal end

Epitope: C-terminus

Application

Detect MRP2 using this Anti-MRP2 Antibody, C-terminus, clone M2 III-6 validated for use in WB, IC, IH, IH(P).

Research Category
Metabolism

Research Sub Category
Toxicology & Drug Resistance

Western blotting: 1:20 - 1:50 with anti-mouse HRP

Immunocytochemistry: 1:20 - 1:50 on acetone fixed cytospin preparations

Immunohistochemistry: 1:20 on acetone fixed frozen tissue sections; 1:20 on formaldehyde-fixed paraffin-embedded tissues (pretreat with 0.01M citrate, pH 6.0, in dH2O at 100ºC for 5 minutes, repeated 3 times)

Optimal working dilutions must be determined by end user.

Physical form

Liquid containing 0.7% BSA and 0.1% sodium azide.

Storage and Stability

Maintain refrigerated at 2-8°C for up to 6 months. For long-term storage store at -20°C.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2