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Key Documents

AB5384

Sigma-Aldrich

Anti-Nitric Oxide Synthase II Antibody

serum, Chemicon®

Sinónimos:

NOS II, iNOS

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... NOS2(4843)

General description

The inducible isoform of the enzyme nitric oxide synthase (iNOS, NOS-II) is synthesized by macrophages and many other cell types in response to proinflammatory cytokines and certain other stimuli, such as hypoxia and stress.

Specificity

Inducible nitric oxide synthase (iNOS, NOS-II). No cross-reaction with nNOS and eNOS by immunohistochemistry. AB5384 reacts with human glia and certain neurons in Alzheimer′s disease by immunohistochemistry.

Immunogen

C-terminal 19 amino acid peptide from human chondrocyte nitric oxide synthase.

Application

Detect Nitric Oxide Synthase II using this Anti-Nitric Oxide Synthase II Antibody validated for use in WB, IH.
Research Category
Neuroscience
Research Sub Category
Oxidative Stress
Western blot: 1:1,000-1:2,500 (ECL).

Immunohistochemistry: 1:2,500-1:6,000 (ABC).

Optimal working dilutions must be determined by end user.

Physical form

Rabbit serum. Liquid containing 0.05% sodium azide.

Storage and Stability

Maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1


Certificados de análisis (COA)

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Imaging pulmonary inducible nitric oxide synthase expression with PET.
Huang, HJ; Isakow, W; Byers, DE; Engle, JT; Griffin, EA; Kemp, D; Brody, SL; Gropler et al.
Journal of Nuclear Medicine null
Protein co-expression with axonal injury in multiple sclerosis plaques.
Maria Diaz-Sanchez, Kelly Williams, Gabriele C DeLuca, Margaret M Esiri
Acta neuropathologica null
Effect of IBD sera on expression of inducible and endothelial nitric oxide synthase in human umbilical vein endothelial cells.
Palatka, K; Serfozo, Z; Vereb, Z; Batori, R; Lontay, B; Hargitay, Z; Nemes, Z; Udvardy et al.
World Journal of Gastroenterology null
Multiple sclerosis deep grey matter: the relation between demyelination, neurodegeneration, inflammation and iron.
Haider, L; Simeonidou, C; Steinberger, G; Hametner, S; Grigoriadis, N; Deretzi, G; Kovacs et al.
Journal of Neurology, Neurosurgery, and Psychiatry null
Disease-specific molecular events in cortical multiple sclerosis lesions.
Fischer, MT; Wimmer, I; Hoftberger, R; Gerlach, S; Haider, L; Zrzavy, T; Hametner et al.
Brain null

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