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AB3081

Sigma-Aldrich

Anti-Na+/H+ Exchanger-1 Antibody

Chemicon®, from rabbit

Sinónimos:

NHE1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human, rat, bovine, mouse, pig

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
western blot: suitable

NCBI accession no.

NM_003047.2

UniProt accession no.

P19634

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... SLC9A1(6548)

Specificity

Recognizes Na+/H+ Exchanger 1 (NHE1). The immunogen peptide shows no significant homology with other NHE isoforms (NHE2-5).

Immunogen

A 22 aa peptide within the cytoplasmic, C-terminal domain of rat NHE1, coupled to KLH.

Application

Detect Na+/H+ Exchanger-1 using this Anti-Na+/H+ Exchanger-1 Antibody validated for use in ELISA & WB.
Western blot: 1-10 μg/mL using Chemiluminescence technique.



ELISA: 1:100,000 using 50-100 ng control peptide per well.

Optimal working dilutions must be determined by end user.

Target description

91 kDa

Physical form

Affinity Purified immunoglobulin. Liquid in PBS and 0.1% BSA .

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Malignant gliomas display altered plasma membrane potential and pH regulation--interaction with Tc-99m-MIBI and Tc-99m-Tetrofosmin uptakes.
N Perek, D Denoyer, F Dubois, F Koumanov
General Physiology and Biophysics null
Bryan J Feger et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 305(10), R1182-R1189 (2013-09-21)
The myocardial Na(+)/H(+) exchanger-1 (NHE1) plays a major role in regulation of intracellular pH, and its upregulation has been implicated in increased ischemia-reperfusion injury and other pathologies. Hydrogen peroxide (H2O2) increases NHE1 activity acutely via ERK1/2 signaling. Chronic strenuous exercise
J Orlowski et al.
The Journal of biological chemistry, 267(13), 9331-9339 (1992-05-05)
Biochemical and pharmacological data support the existence of multiple forms of the Na/H exchanger (NHE). Two isoforms, termed NHE-1 and NHE-2, have recently been isolated from rabbit ileal villus epithelial cells (Tse, C. M., Ma, A. I., Yang, V. W.
Danny Christiansen et al.
Acta physiologica (Oxford, England), 231(3), e13580-e13580 (2020-11-23)
To assess how blood-flow-restricted (BFR) interval-training affects the capacity of the leg muscles for pH regulation during dynamic exercise in physically trained men. Ten men (age: 25 ± 4y; V˙O2max : 50 ± 5 mL∙kg-1 ∙min-1 ) completed a 6-wk interval-cycling intervention (INT) with one
C H Yun et al.
The American journal of physiology, 269(1 Pt 1), G1-11 (1995-07-01)
Na+/H+ exchangers are integral plasma membrane proteins that exchange extracellular Na+ for intracellular H+ with a stoichiometry of one for one. They are inhibitable by the diuretic amiloride and have multiple cellular functions, including intracellular pH homeostasis, cell volume control
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