528122

PI 3,4-K inhibitor, PIK-93

The PI 3,4-K inhibitor, PIK-93, also referenced under CAS 593960-11-3, controls the biological activity of PI 3,4-K. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinónimos: PI 3,4-K inhibitor, PIK-93, N-(5-(4-Chloro-3-(((2-hydroxyethyl)amino)sulfonyl)phenyl)-4-methyl-2-thiazolyl)-acetamide
• Fórmula empírica (notación de Hill): C₁₄H₁₆ClN₃O₄S₂
• Número de CAS: 593960-11-3
• Peso molecular: 389.88
• MDL number: MFCD12922510
• UNSPSC Code: 12352200

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: pale yellow
• solubility: DMSO: 50 mg/mL, pale yellow
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: ClC1=CC=C(C2=C(C)N=C(NC(C)=O)S2)C=C1S(NCCO)(=O)=O
• InChI: 1S/C14H16ClN3O4S2/c1-8-13(23-14(17-8)18-9(2)20)10-3-4-11(15)12(7-10)24(21,22)16-5-6-19/h3-4,7,16,19H,5-6H2,1-2H3,(H,17,18,20)
• InChI key: JFVNFXCESCXMBC-UHFFFAOYSA-N

Descripción

General description

A cell-permeable phenylthiazole compound that acts as a potent, reversible and ATP-competitive PI 3,4-K family selective inhibitor (IC₅₀ = 16, 19, 39 and 64 nM for p110γ, PI 4-KIIIβ, p110α and DNA-PK, respectively). Moderately inhibits p110δ, PI 3-KC2β, hsVPS34, ATM, p110β and PI 4-KIIIα (IC₅₀ = 0.120, 0.140, 0.320, 0.490, 0.590 and 1.1 µM, respectively) with minimal inhibition towards a panel of 36-kinases (IC₅₀ >10 µM). Shown to block ceramide transfer protein-mediated ceramide traffic between endoplasmic reticulum and Golgi in transfected COS-7 cells at 250 nM.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Miller, S., et al. 2010. Science327, 1638.
Fan, Q.W., et al. 2006. Cancer Cell9, 341.
Toth, B., et al. 2006. J. Biol. Chem.281, 36369.
Knight, Z.A., et al. 2006. Cell125, 733.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable