5.05226

Pancuronium Dibromide

• Sinónimos: Pancuronium Dibromide, 1,1ʹ-(3α,17β-Dihydroxy-2α,5β-androstan-2-β,16β-ylene) bis[1-methylpiperidinium] diacetate dibromide, Nicotinic Acetylchorine Receptor Antagonist, Pancuronium Dibromide, nAChR Antagonist, Pancuronium Dibromide
• Fórmula empírica (notación de Hill): C₃₅H₆₀N₂O₄ · Br₂
• Número de CAS: 15500-66-0
• Peso molecular: 732.67
• MDL number: MFCD00079223
• UNSPSC Code: 12352200

Propiedades

• assay: ≥98% (NMR)
• Quality Level: 100
• form: solid
• potency: 5.5 nM IC₅₀
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: off-white
• solubility: water: 100 mM
• storage temp.: 2-8°C
• InChI: 1S/C35H60N2O4.2BrH/c1-24(38)40-32-21-26-13-14-27-28(35(26,4)23-31(32)37(6)19-11-8-12-20-37)15-16-34(3)29(27)22-30(33(34)41-25(2)39)36(5)17-9-7-10-18-36;;/h26-33H,7-23H2,1-6H3;2*1H/q+2;;/p-2/t26-,27+,28-,29-,30-,31-,32-,33-,34-,35-;;/m0../s1
• InChI key: NPIJXCQZLFKBMV-YTGGZNJNSA-L

Descripción

General description

A highly potent competitive antagonist selective for nAChRs (IC₅₀ = 5.5 nM). A very potent non-depolarizing skeletal muscle relaxant but no sedative or analgesic effects.

Biochem/physiol Actions

Primary Target
nAChR

Warning

Toxicity: Toxic (F)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Lowenick et al., 2001. Eur. J. Pharmacol.413, 31.

Melnikov, L., et al., 1999. Gen Pharmacol.33, 313.

Maestrone, E., et al., 1994. Br. J. Pharmacol.111, 283.

Fryer, D., et al., 1987. Naunyn Schmiedebergs Arch. Pharmacol.335, 367.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable