407306
γ-Interferon, Human, Recombinant, E. coli
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.77
Productos recomendados
form
liquid
Quality Level
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
shipped in
wet ice
storage temp.
−20°C
General description
Recombinant, human γ-interferon expressed in E. coli. A multi-functional protein consisting of 144 amino acids. Exhibits antiviral and antitumor properties. Regulates the development of specific immune responses. Expressed in and purified from E. coli.
Recombinant, human γ-interferon expressed in E. coli. A multi-functional protein consisting of 144 amino acids. Exhibits antiviral and antitumor properties. Regulates the development of specific immune responses.
Biochem/physiol Actions
ED₅₀ = 0.5-3.0 ng/ml as measured by inhibition (cytostasis) of human WiDr cells.
Packaging
Please refer to vial label for lot-specific concentration.
Warning
Toxicity: Standard Handling (A)
Physical form
Sterile-filtered (0.22 µm) in 40 mM Tris-HCl, pH 7.4, carrier-free.
Reconstitution
Following initial thaw, aliquot and freeze (-20°C). Do not store in glass vials without addition of carrier protein. Further dilute in low endotoxin medium or buffer containing FBS or tissue culture grade BSA.
Other Notes
Kohji, K., et al. 1994. J. Int. J. Cancer 58, 380.
Kolb, J.P., et al. 1994. J. Biol. Chem.269, 9811.
Müller, U., et al. 1994. Science264, 1918.
Zahedi, K., et al. 1994. J. Biol. Chem.269, 9669.
Shuai, K., et al. 1993. Science261, 1744.
Wilson, K.C., and Finbloom, D.S. 1992. Proc. Natl. Acad. Sci. USA89, 11964.
Meager, A. 1987. Lymphokines and Interferons, A Practical Approach (Clemens, M.J., et al., eds.) p. 129, IRL Press, Oxford.
Kolb, J.P., et al. 1994. J. Biol. Chem.269, 9811.
Müller, U., et al. 1994. Science264, 1918.
Zahedi, K., et al. 1994. J. Biol. Chem.269, 9669.
Shuai, K., et al. 1993. Science261, 1744.
Wilson, K.C., and Finbloom, D.S. 1992. Proc. Natl. Acad. Sci. USA89, 11964.
Meager, A. 1987. Lymphokines and Interferons, A Practical Approach (Clemens, M.J., et al., eds.) p. 129, IRL Press, Oxford.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Christin Pelzel et al.
Molecular cell, 50(1), 149-156 (2013-04-16)
Signal transducer and activator of transcription 1 (STAT1) is activated by tyrosine phosphorylation upon interferon-γ (IFNγ) stimulation, which results in the expression of genes with antiproliferative and immunomodulatory functions. The inactivation of STAT1 occurs through tyrosine dephosphorylation by the tyrosine
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