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Key Documents

164598

Sigma-Aldrich

Aminopeptidase M, Porcine Kidney

Sinónimos:

Aminopeptidase M, Porcine Kidney, Alanyl aminopeptidase, Aminopeptidase M, Aminopeptidase N

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About This Item

Número de CAS:
Comisión internacional de enzimas:
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.54

biological source

Porcine kidney

Quality Level

form

suspension (crystalline)

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

physiological buffer: soluble
water: soluble

foreign activity

Oxidases ≤3%

shipped in

ambient

storage temp.

2-8°C

General description

Aminopeptidase M (APM) is abundantly found in brush border membranes of the kidney, small intestine, placenta, and liver. It is a type II integral membrane protein, known as ectoenzyme.

Application

Aminopeptidase M, porcine kidney has been used:
  • to test and identify the peaks containing d-residue in the allatotropin-related peptide (ATRP)
  • to study its oxidative inactivation of enzyme activity, and to screen MIRA ingredients
  • for the proteolysis of isolevuglandins (IsoLGs) proteins

Biochem/physiol Actions

Aminopeptidase M (APM) is implicated in terminating the actions of certain neuropeptides, like the enkephalins and angiotensin III in the brain. It also metabolizes specific vasoactive peptides. It functions as a receptor for certain viruses, such as coronavirus 229E. APM is a nonspecific peptidase, which rapidly breaks down l-residue peptides.

Packaging

Please refer to vial label for lot-specific concentration.

Warning

Toxicity: Harmful (C)

Unit Definition

One unit is defined as the amount of enzyme that will hydrolyze 1 µmol of Leu-pNA per min at 37°C, pH 7.2.

Physical form

Crystalline suspension in 3.2 M (NH₄)₂SO₄, 10 mM MgCl₂, 10 mM Tris-HCl, pH 7.5.

Other Notes

Wachsmuth, E.E., et al. 1966. Biochemistry5, 169.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Handbook of Proteolytic Enzymes (2012)

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