14-721-M

EGFR (T790M, L858R) Protein, active, 10 µg

Active, N-terminal GST-tagged, recombinant human EGFR, amino acids 696-end containing the mutations T790M & L858R, for use in Enzyme Assays.

• UNSPSC Code: 12352202
• eCl@ss: 32160405
• NACRES: NA.32

Propiedades

• biological source: human
• Quality Level: 100
• recombinant: expressed in baculovirus infected Sf21 cells
• product line: Upstate^®
• specific activity: (For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)
• mol wt: M_w 85.8 kDa
• purified by: (Glutathione-agarose)
• species reactivity: human
• manufacturer/tradename: Upstate^®
• technique(s): activity assay: suitable
• accession no.: (FUNCTION: SwissProt: P00533 # Isoform 2/truncated isoform may act as an antagonist. ); NM_005228.3
• NCBI accession no.: NM_005228.3; NM_201282.1; NM_201283.1; NM_201284.1
• UniProt accession no.: P00533
• relevant disease(s): arthritis; obesity; osteoporosis; metabolic disorders

Descripción

General description

N-terminal GST-tagged, recombinant human EGFR, amino acids 696end containing the mutations T790M and L858R

Application

Research Category
Metabolism

Inflammation & Immunology

Research Sub Category
Obesity

Metabolic Disorders

Osteoporosis

Arthritis

Biochem/physiol Actions

Protein Target: EGFR

Target Sub-Family: TK

Packaging

Also available in 10 μg size and in bulk

Quality

routinely evaluated by phosphorylation of 250μM substrate peptide (GGMEDIYFEFMGGKKK)

Target description

EGFR

Physical form

Glutathione-agarose

Storage and Stability

6 months at -70°C from date of shipment

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H317
• pcodes: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_c: Not applicable