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Merck
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Key Documents

07-886

Sigma-Aldrich

Anti-phospho-PKR (Thr451) Antibody

Upstate®, from rabbit

Sinónimos:

EIF2AK2 (eukaryotic translation initiation factor 2-alpha kinase 2), EIF2AK1, MGC126524, PKR, PRKR

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse, human

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

NM_002759.1

UniProt accession no.

P19525

shipped in

dry ice

target post-translational modification

phosphorylation (pThr451)

Gene Information

human ... EIF2AK2(5610)
mouse ... Eif2Ak2(19106)

Specificity

Recognizes phosphorylated PKR (Thr451)

Immunogen

Peptide corresponding to amino acid region encompassing the human phospho-PKR (Thr451)

Application

Research Category
Signaling
Research Sub Category
Cytoskeletal Signaling
This Anti-phospho-PKR (Thr451) Antibody is validated for use in WB for the detection of phospho-PKR (Thr451).

Quality

Routinely evaluated by immunoblot.

Target description

68 kDa

Physical form

100 µL of affinity purified rabbit polyclonal IgG in Dulbecco’s PBS, containing 1.0 mg/mL BSA, 0.05% sodium azide and 50% glycerol.
ImmunoAffinity Purified

Storage and Stability

Stable for 2 years at -20°C from date of shipment.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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P R Romano et al.
Molecular and cellular biology, 18(4), 2282-2297 (1998-04-07)
The human double-stranded RNA-dependent protein kinase (PKR) is an important component of the interferon response to virus infection. The activation of PKR is accompanied by autophosphorylation at multiple sites, including one in the N-terminal regulatory region (Thr-258) that is required
Mechanisms that lessen benefits of ?-secretase reduction in a mouse model of Alzheimer's disease.
Devi, L; Ohno, M
Translational Psychiatry null
Latha Devi et al.
PloS one, 8(10), e77335-e77335 (2013-10-23)
Emerging evidence suggests that dysregulated translation through phosphorylation of eukaryotic initiation factor-2α (eIF2α) may contribute to Alzheimer's disease (AD) and related memory impairments. However, the underlying mechanisms remain unclear. Here, we crossed knockout mice for an eIF2α kinase (GCN2: general
Wei Li et al.
Scientific reports, 8(1), 166-166 (2018-01-11)
Cytoplasmic membrane-bound connexin 43 (Cx43) proteins oligomerize into hexameric channels (hemichannels) that can sometimes dock with hemichannels on adjacent cells to form gap junctional (GJ) channels. However, the possible role of Cx43 hemichannels in sterile and infectious inflammatory diseases has
Bruna T Dias et al.
Frontiers in immunology, 13, 801182-801182 (2022-02-15)
Leishmania donovani is a protozoan parasite that causes visceral leishmaniasis, provoking liver and spleen tissue destruction that is lethal unless treated. The parasite replicates in macrophages and modulates host microbicidal responses. We have previously reported that neutrophil elastase (NE) is
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