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Merck
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Key Documents

07-794

Sigma-Aldrich

Anti-Rab13 Antibody

Upstate®, from rabbit

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human, rat, mouse

manufacturer/tradename

Upstate®

technique(s)

immunofluorescence: suitable
immunoprecipitation (IP): suitable
western blot: suitable

NCBI accession no.

NP_002861

UniProt accession no.

P51153

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... RAB13(5872)

General description

Rab proteins are members of the Ras superfamily of small G-Proteins. At least 60 isoforms have been identified. These GTPases are primarily involved in vesicle trafficking and it is believed that a different Rab protein may be needed for each step of the vesicular transport. It is thought Rab4 and Rab11 are involved in internalization, sorting, and transport to lysosomes or recycling, of several membrane proteins, including GPCRs, GLUT-4, Aquaporin-2, or the H+/K+ ATPase.

Specificity

Recognizes Rab13

Immunogen

Sythnetic peptide of amno acids 129-148 of rat Rab13

Application

Detect Rab13 using this Anti-Rab13 Antibody validated for use in WB, IP & IF.
Immunofluorescence Staining:
Independent laboratory demonstrated this antibody worked in Immunofluorescence studies at a 1:100-1:500 dilution.

Immunoprecipitation (IP):
Independent laboratory demonstrated this antibody works in Immunoprecipitation.

Quality

Western Blot Analysis:
This lot detected Rab13 at 1:1,000 (1g/mL) dilution in lysates from PC12 lysate resolved via SDS-PAGE and transferred to PVDF (Immobilon-P).

Target description

25 kDa

Physical form

Affinity Purified rabbit IgG in storage buffer containing tri-citrate-phosphate, pH 7-8 and 0.1% sodium azide.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Katja Köhler et al.
The Journal of cell biology, 165(2), 175-180 (2004-04-21)
The GTPase Rab13 regulates the assembly of functional epithelial tight junctions (TJs) through a yet unknown mechanism. Here, we show that expression of the GTP-bound form of Rab13 inhibits PKA-dependent phosphorylation and TJ recruitment of the vasodilator-stimulated phosphoprotein, an actin
I Kanda et al.
Oncogene, 27(12), 1687-1695 (2007-09-25)
Epithelial cell scattering recapitulates the first steps of carcinoma invasion/metastasis. While the balance between cell-cell adhesive activity and cell motility ultimately determines this process, its molecular mechanisms remain unclear. Adherence junctions and tight junctions (TJs) are primarily responsible for cell-cell
Shinya Morimoto et al.
The Journal of biological chemistry, 280(3), 2220-2228 (2004-11-06)
During epithelial morphogenesis, adherens junctions (AJs) and tight junctions (TJs) undergo dynamic reorganization, whereas epithelial polarity is transiently lost and reestablished. Although ARF6-mediated endocytic recycling of E-cadherin has been characterized and implicated in the rapid remodeling of AJs, the molecular
Simone Di Giovanni et al.
The Journal of biological chemistry, 280(3), 2084-2091 (2004-11-04)
Following spinal cord injury, there are numerous changes in gene expression that appear to contribute to either neurodegeneration or reparative processes. We utilized high density oligonucleotide microarrays to examine temporal gene profile changes after spinal cord injury in rats with

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