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Merck
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Key Documents

07-678

Sigma-Aldrich

Anti-LINGO-1 Antibody

Upstate®, from rabbit

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, human, rat

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

NM_032808.5

UniProt accession no.

Q96FE5

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

mouse ... Lingo1(235402)

Specificity

LINGO-1

Immunogen

KLH-conjugated, synthetic peptide corresponding to amino acid residues 611-620 of human LINGO-1 (APRKFNMKMI)

Application

Detect LINGO-1 using this Anti-LINGO-1 Antibody validated for use in WB.
Research Category
Neuroscience
Research Sub Category
Neurodegenerative Diseases

Quality

routinely evaluated by immunoblot on mouse brain membrane samples.

Target description

Mr ~83kDa

Physical form

Format: Purified
Protein A purified

Storage and Stability

stable for 2 years at -20°C from date of shipment

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

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Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Sha Mi et al.
Nature neuroscience, 7(3), 221-228 (2004-02-18)
Axon regeneration in the adult CNS is prevented by inhibitors in myelin. These inhibitors seem to modulate RhoA activity by binding to a receptor complex comprising a ligand-binding subunit (the Nogo-66 receptor NgR1) and a signal transducing subunit (the neurotrophin
Lingo-1 expression is increased in essential tremor cerebellum and is present in the basket cell pinceau.
Kuo, SH; Tang, G; Louis, ED; Ma, K; Babji, R; Balatbat, M; Cortes, E; Vonsattel et al.
Acta neuropathologica null
From cell death to neuronal regeneration, effects of the p75 neurotrophin receptor depend on interactions with partner subunits.
Bandtlow, Christine and Dechant, Georg
Science's STKE : Signal Transduction Knowledge Environment, 2004, pe24-pe24 (2004)
Alexandra Trifunovski et al.
Neuroreport, 15(15), 2397-2400 (2005-01-11)
Axonal regeneration after injury can be limited in the adult CNS by the presence of inhibitory proteins such as Nogo. Nogo binds to a receptor complex that consists of Nogo receptor (NgR), p75NTR, and Lingo-1. Nogo binding activates RhoA, which
Multi-tasking by the p75 neurotrophin receptor: sortilin things out?
Bronfman, Francisca C and Fainzilber, Mike
EMBO Reports, 5, 867-871 (2004)
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