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Merck
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Key Documents

07-464

Sigma-Aldrich

Anti-Vav3 Antibody, human

Upstate®, from rabbit

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

manufacturer/tradename

Upstate®

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG

NCBI accession no.

NM_006113

UniProt accession no.

Q9UKW4

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... VAV3(10451)

Specificity

Vav3

Immunogen

KLH-conjugated, synthetic peptide corresponding to amino acids 566-591of human Vav3.

Application

Anti-Vav3 Antibody, human detects level of Vav3 & has been published & validated for use in IP, WB, IC, IH.
Research Category
Signaling
Research Sub Category
Cytoskeletal Signaling

Quality

routinely evaluated by immunoblot in RIPA lysates from HeLa and Jurkat cells

Target description

98 kDa

Physical form

0.1M Tris-glycine, pH 7.4, 0.15M NaCl,0.05% sodium azide before the addition of glycerol to 30%
Format: Purified
Protein A purified

Storage and Stability

2 years at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

VAV proteins as signal integrators for multi-subunit immune-recognition receptors.
Turner, Martin and Billadeau, Daniel D
Nature Reviews: Immunology, 2, 476-486 (2002)
Youjia Cao et al.
The EMBO journal, 21(18), 4809-4819 (2002-09-18)
The Rac/Rho-specific guanine nucleotide exchange factor, Vav-1, is a key component of the T-cell antigen receptor (TCR)-linked signaling machinery. Here we have used somatic cell gene-targeting technology to generate a Vav-1-deficient Jurkat T-cell line. The J.Vav1 cell line exhibits dramatic
Mapping cell-matrix stresses during stretch reveals inelastic reorganization of the cytoskeleton.
Nuria Gavara,Pere Roca-Cusachs,Raimon Sunyer,Ramon Farre,Daniel Navajas
Biophysical Journal null
Emanuela Dylgjeri et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 25(18), 5623-5637 (2019-07-04)
DNA-dependent protein kinase catalytic subunit (DNA-PK) is a pleiotropic kinase involved in DNA repair and transcriptional regulation. DNA-PK is deregulated in selected cancer types and is strongly associated with poor outcome. The underlying mechanisms by which DNA-PK promotes aggressive tumor
Mehdi Badaoui et al.
Cell reports, 32(1), 107842-107842 (2020-07-09)
Pseudomonas aeruginosa (Pa) represents the leading cause of airway infection in cystic fibrosis (CF). Early airways colonization can be explained by enhanced adhesion of Pa to the respiratory epithelium. RNA sequencing (RNA-seq) on fully differentiated primary cultures of airway epithelial
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