07-373
Anti-acetyl-Histone H2B Antibody
Upstate®, from rabbit
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Productos recomendados
biological source
rabbit
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
acetylation (Lys5,Lys12,Lys15,Lys20)
Gene Information
human ... H2BC1(255626)
Categorías relacionadas
Specificity
acetylated Histone H2B
Immunogen
Synthetic peptide in which there is an acetyl-lysine at residues 5, 12, 15 and 20 of human Histone H2B
Application
Detect acetyl-Histone H2B also known as Histone H2B with Anti-acetyl-Histone H2B Antibody (Rabbit Polyclonal Antibody), that has been demonstrated to work in WB.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Histones
Histones
Quality
routinely evaluated by immunoblot in sodium butyrate treated, acid extracted proteins from HeLa cells
Target description
15 kDa
Physical form
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Format: Purified
Protein A chromatography
Storage and Stability
2 years at -20°C
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Spatial memory consolidation is associated with induction of several lysine-acetyltransferase (histone acetyltransferase) expression levels and H2B/H4 acetylation-dependent transcriptional events in the rat hippocampus.
Bousiges, O; Vasconcelos, AP; Neidl, R; Cosquer, B; Herbeaux, K; Panteleeva, I; Loeffler et al.
Neuropsychopharmacology null
Snehajyoti Chatterjee et al.
EMBO molecular medicine, 10(11) (2018-10-03)
Chromatin acetylation, a critical regulator of synaptic plasticity and memory processes, is thought to be altered in neurodegenerative diseases. Here, we demonstrate that spatial memory and plasticity (LTD, dendritic spine formation) deficits can be restored in a mouse model of
A novel activator of CBP/p300 acetyltransferases promotes neurogenesis and extends memory duration in adult mice.
Chatterjee, S; Mizar, P; Cassel, R; Neidl, R; Selvi, BR; Mohankrishna, DV; Vedamurthy et al.
The Journal of Neuroscience null
Frederick A Schroeder et al.
PloS one, 8(8), e71323-e71323 (2013-08-24)
Psychiatric diseases, including schizophrenia, bipolar disorder and major depression, are projected to lead global disease burden within the next decade. Pharmacotherapy, the primary--albeit often ineffective--treatment method, has remained largely unchanged over the past 50 years, highlighting the need for novel
Benjamin E L Lauffer et al.
The Journal of biological chemistry, 288(37), 26926-26943 (2013-07-31)
Histone deacetylases (HDACs) are critical in the control of gene expression, and dysregulation of their activity has been implicated in a broad range of diseases, including cancer, cardiovascular, and neurological diseases. HDAC inhibitors (HDACi) employing different zinc chelating functionalities such
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