Saltar al contenido
Merck

Z-013

Supelco

Zopiclone-N-oxide solution

100 μg/mL (Methanol with 1% 1 M HCl), ampule of 1 mL, certified reference material, Cerilliant®

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización


About This Item

Fórmula empírica (notación de Hill):
C17H17ClN6O4
Número de CAS:
Peso molecular:
404.81
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material

form

liquid

feature

(Snap-N-Spike®)

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

100 μg/mL (Methanol with 1% 1 M HCl)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

O=C1N(C2=CC=C(Cl)C=N2)C(OC(N3CC[N+]([O-])(C)CC3)=O)C4=C1N=CC=N4

InChI

1S/C17H17ClN6O4/c1-24(27)8-6-22(7-9-24)17(26)28-16-14-13(19-4-5-20-14)15(25)23(16)12-3-2-11(18)10-21-12/h2-5,10,16H,6-9H2,1H3

InChI key

IPTIKKTXLHVRKN-UHFFFAOYSA-N

¿Está buscando productos similares? Visita Guía de comparación de productos

General description

Zopiclone N-oxide is a primary, active metabolite of zopiclone in urine as well as a major pharmaceutical impurity of zopiclone known as eszopiclone impurity A. The parent drug, zopiclone, is a non-benzodiazepine hypnotic sold under the trade names Imovane®and ZImovane®and is used in the treatment of insomnia.

Application


  • Enantioselective analysis of zopiclone and its metabolites: A study developed a DLLME-CE method for the enantioselective analysis of zopiclone and its active metabolite, zopiclone-N-oxide, post fungal biotransformation, demonstrating the utility of zopiclone-N-oxide as a reference standard in pharmaceutical metabolite profiling (de Albuquerque et al., 2015).

  • Pharmacokinetic studies: An analytical method using liquid chromatography/tandem mass spectrometry was employed for the enantioselective analysis of zopiclone and its metabolites in plasma, showcasing zopiclone-N-oxide′s critical role in bioanalytical studies related to insomnia and GABA receptor modulation (Tonon et al., 2011).


Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Imovane is a registered trademark of Sanofi-Aventis
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Artículos

An rapid method for the siµLtaneous determination of the Z-drugs or sleep aids: zopiclone, zolpidem, and zaleplon is presented here. The need for greater analytical capacity and throughput for the analysis of sleep aid medicines (Z-drugs) in forensic toxicology laboratories can be met by the use of fast Ascentis Express 2.0 micron Fused Core UHPLC Columns.

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico