T-911

α-Hydroxytriazolam solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Fórmula empírica (notación de Hill): C₁₇H₁₂Cl₂N₄O
• Número de CAS: 37115-45-0
• Peso molecular: 359.21
• EC Number: 200-659-6
• UNSPSC Code: 41116107
• NACRES: NA.24

Propiedades

• grade: certified reference material
• Quality Level: 300
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 1.0 mg/mL in methanol
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): clinical testing
• format: single component solution
• storage temp.: 2-8°C
• SMILES string: OCc1nnc2CN=C(c3ccccc3Cl)c4cc(Cl)ccc4-n12
• InChI: 1S/C17H12Cl2N4O/c18-10-5-6-14-12(7-10)17(11-3-1-2-4-13(11)19)20-8-15-21-22-16(9-24)23(14)15/h1-7,24H,8-9H2
• InChI key: BHUYWUDMVCLHND-UHFFFAOYSA-N

Descripción

General description

a-Hydroxytriazolam is a major urinary and blood metabolite of the benzodiazepine, triazolam, a pharmaceutical used to treat severe insomnia. This certified solution standard is suitable for use in LC/MS or GC/MS applications for clinical toxicology, forensic analysis, urine drug testing, or pharmaceutical research.

Application

• Pharmacokinetic analysis of benzodiazepines: alpha-Hydroxytriazolam solution is employed in the quantitation of benzodiazepines and their metabolites in biological fluids using liquid chromatography-tandem mass spectrometry, providing accurate pharmacokinetic profiles that are essential for clinical and forensic analysis (Zheng et al., 2018).


• Receptor binding studies: The application of high-purity alpha-Hydroxytriazolam in receptor binding studies enables researchers to elucidate the interaction mechanisms of benzodiazepine analogs at the molecular level, thereby enhancing the understanding of their pharmacological effects (Minegishi et al., 2021).


• Development of analytical methods: alpha-Hydroxytriazolam solution serves as a critical analytical standard in the development of robust assays for the detection and quantification of benzodiazepines in various matrices, facilitating advancements in toxicological and pharmacological research (Lahr et al., 2020).


• Forensic and clinical toxicology: Utilized in forensic science, alpha-Hydroxytriazolam solution aids in the rapid determination of benzodiazepines and their metabolites in urine samples, crucial for the accurate interpretation of toxicological data (Jeong et al., 2015).


• Scientific research in biochemistry: alpha-Hydroxytriazolam research compounds are vital for studying the metabolic pathways and degradation profiles of triazolam and related benzodiazepines, supporting biochemists in drug metabolism and pharmacokinetics research (Jin et al., 2011).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• pictograms: GHS02,GHS06,GHS08
• signalword: Danger
• hcodes: H225,H301 + H311 + H331,H370
• pcodes: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• target_organs: Eyes,Central nervous system
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 2
• flash_point_f: 49.5 °F - closed cup
• flash_point_c: 9.7 °C - closed cup