N-077

(S)-N-Nitrosoanabasine (NAB) solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Sinónimos: NAB, NAB solution
• Fórmula empírica (notación de Hill): C₁₀H₁₃N₃O
• Número de CAS: 1133-64-8
• Peso molecular: 191.23
• EC Number: 200-659-6
• MDL number: MFCD01669936
• UNSPSC Code: 41116107
• PubChem Substance ID: 329818460
• NACRES: NA.24

Propiedades

• grade: certified reference material
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 1.0 mg/mL in methanol
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): forensics and toxicology
• format: single component solution
• storage temp.: −20°C
• SMILES string: O=NN1CCCC[C@H]1c2cccnc2
• InChI: 1S/C10H13N3O/c14-12-13-7-2-1-5-10(13)9-4-3-6-11-8-9/h3-4,6,8,10H,1-2,5,7H2/t10-/m0/s1
• InChI key: BXYPVKMROLGXJI-JTQLQIEISA-N

Descripción

General description

N-Nitrosoanabasine or NAB is a potent carcinogen and biomarker of exposure to cigarette smoke. It′s found in a variety of tobacco products including chewing tobacco and snuff. This Certified Spiking Solution^® is suitable for use in LC-MS/MS or GC/MS methods for nicotine testing, environmental monitoring, or clinical and diagnostic testing of nicotine biomarkers.

Application

• Inhibitory effects in toxicological studies: (S)-N-Nitrosoanabasine (NAB) has been used in research to investigate its inhibitory effects on the metabolism of the tobacco-specific nitrosamine, NNK, by cytochrome P450 2A13, highlighting its utility in carcinogenicity studies and its role as a research chemical in understanding biochemical pathways involved in cancer (Liu et al., 2016).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTIONS is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• pictograms: GHS02,GHS06,GHS08
• signalword: Danger
• hcodes: H225,H301 + H311 + H331,H370
• pcodes: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• target_organs: Eyes
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 1
• flash_point_f: 49.5 °F - closed cup
• flash_point_c: 9.7 °C - closed cup