860535P

Glucosyl(β) Sphingosine (d18:1)

Avanti Research^™ - A Croda Brand

• Sinónimos: D-glucosyl-β1-1′-D-erythro-sphingosine, Glucosylsphingosine
• Fórmula empírica (notación de Hill): C₂₄H₄₇NO₇
• Número de CAS: 52050-17-6
• Peso molecular: 461.63
• UNSPSC Code: 12352211
• NACRES: NA.25

Propiedades

• form: powder
• packaging: pkg of 1 × 25 mg (860535P-25mg); pkg of 1 × 5 mg (860535P-5mg); pkg of 1 × 50 mg (860535P-50mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand
• lipid type: sphingolipids
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@](N)([H])CO[C@H](O1)[C@H](O)[C@@H](O)[C@@H]([C@H]1CO)O
• InChI: 1S/C24H47NO7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(27)18(25)17-31-24-23(30)22(29)21(28)20(16-26)32-24/h14-15,18-24,26-30H,2-13,16-17,25H2,1H3/b15-14+/t18?,19-,20-,21-,22+,23+,24-/m1/s1
• InChI key: HHJTWTPUPVQKNA-SKXACSAKSA-N

Descripción

General description

Glucosyl sphingosine is a lyso derivative of glucosylceramide (GlcCer).

Application

Glucosyl(β) Sphingosine (d18:1) or D-glucosyl-β1-1′-D-erythro-sphingosine may be used:

• to screen lipids that rapidly and reversibly alter transepithelial electrical resistance (TER) or tight junction (TJ) permeability in epithelial tissue
• as a standard for the quantification of glucosyl sphingosine in Gaucher patients using liquid chromatography electrospray ionization tandem mass spectrometric (LC/ESI-MS/MS)
• as an internal standard for the quantification of lysoglucosylceramide in plasma for Gaucher disease using liquid chromatography with tandem mass spectrometry (LC-MS/MS)

Biochem/physiol Actions

Glucosyl sphingosine is a potential biomarker for Gaucher′s disease. It modulates Ca²⁺ release in the brain microsomes.

Packaging

5 mL Amber Glass Screw Cap Vial (860535P-25mg)

5 mL Amber Glass Screw Cap Vial (860535P-50mg)

5 mL Amber Glass Screw Cap Vial (860535P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable