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850200P

Avanti

Regadenoson

2-[4-[(methylamino)carbonyl]-1H-pyrazol-1-yl]adenosine, powder

Sinónimos:

Lexiscan; CVT-3146

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About This Item

Fórmula empírica (notación de Hill):
C15H18N8O5
Número de CAS:
313348-27-5
Peso molecular:
390.35
MDL number:
MFCD09832544
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 5 mg (850200P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 850200P

application(s)

lipidomics
metabolomics

shipped in

dry ice

storage temp.

−20°C

SMILES string

[n]4(ncc(c4)C(=O)NC)c1nc2[n](cnc2c(n1)N)[C@@H]3O[C@@H]([C@H]([C@H]3O)O)CO

InChI

1S/C15H18N8O5/c1-17-13(27)6-2-19-23(3-6)15-20-11(16)8-12(21-15)22(5-18-8)14-10(26)9(25)7(4-24)28-14/h2-3,5,7,9-10,14,24-26H,4H2,1H3,(H,17,27)(H2,16,20,21)/t7-,9-,10-,14-/m1/s1

InChI key

LZPZPHGJDAGEJZ-AKAIJSEGSA-N

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General description

Regadenoson is an adenosine analog.

Biochem/physiol Actions

Regadenoson (Lexiscan) is an A2A adenosine receptor agonist used as a coronary vasodilator in pharmacologic stress testing. Recently, it has been demonstrated that regadenoson can temporarily disrupt the integrity of the blood-brain barrier (BBB) by inhibiting P-glycoprotein function.
Regadenoson can be used in patients with obstructive lung disease and renal impairment for myocardial perfusion imaging (MPI).

Packaging

5 mL Amber Glass Screw Cap Vial (850200P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

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Certificados de análisis (COA)

Lot/Batch Number

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Manuel D Cerqueira
The American journal of cardiology, 94(2A), 33D-40D (2004-07-21)
Adenosine and dipyridamole, the currently available vasodilators for myocardial perfusion imaging, produce hyperemic coronary flow by stimulating A(2A) adenosine receptors on arteriolar vascular smooth muscle cells. However, both vasodilators nonselectively activate A(1), A(2B), and A(3) adenosine receptors, which contributes to
Do-Geun Kim et al.
The Journal of clinical investigation, 126(5), 1717-1733 (2016-04-05)
The blood-brain barrier (BBB) protects the brain from toxic substances within the peripheral circulation. It maintains brain homeostasis and is a hurdle for drug delivery to the CNS to treat neurodegenerative diseases, including Alzheimer's disease and brain tumors. The drug
G M Bengalorkar et al.
Journal of postgraduate medicine, 58(2), 140-146 (2012-06-22)
Single-photon emission computerized tomography for myocardial perfusion imaging (MPI) is a non-invasive technique. MPI is performed by subjecting the patient to exercise or by using a pharmacological stress agent. Regadenoson is a selective A 2A adenosine receptor agonist used when

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