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840074C

Avanti

Soy PA

Avanti Research™ - A Croda Brand 840074C

Sinónimos:

L-α-phosphatidic acid (Soy) (sodium salt)

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About This Item

Número de CAS:
475995-54-1
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (840074C-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 840074C

concentration

10 mg/mL (840074C-25mg)

lipid type

phosphoglycerides

shipped in

dry ice

storage temp.

−20°C

General description

Phosphatidic acid (PA) is a diacyl-glycerophospholipid, with two fatty acids and a phosphate group that are covalently attached to a glycerol molecule through ester linkages. PA is rich in soy lecithin. PA is produced endogenously by the hydrolytic action of the enzyme phospholipase D. It is also produced through phosphorylation of diacyl glycerol (DAG) by diacylglycerol kinases (DGKs).

Application

Soy PA is suitable for use in validation of PA probe.

Biochem/physiol Actions

Phosphatidic acid (PA) is present in biomembranes. It is the precursor for other phospholipids and acts as a signaling molecule. PA is implicated in NAPDH oxidase (NOX) activity.

Packaging

5 mL Clear Glass Sealed Ampule (840074C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

wgk_germany

WGK 3

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Diacylglycerol kinases terminate diacylglycerol signaling during the respiratory burst leading to heterogeneous phagosomal NADPH oxidase activation
Schlam D, et al.
Journal of biological and chemical chronicles, 288(32), 23090-23104 (2013)
Daniel Schlam et al.
The Journal of biological chemistry, 288(32), 23090-23104 (2013-07-03)
It is commonly assumed that all phagosomes have identical molecular composition. This assumption has remained largely unchallenged due to a paucity of methods to distinguish individual phagosomes. We devised an assay that extends the utility of nitro blue tetrazolium for
The mitotic and metabolic effects of phosphatidic acid in the primary muscle cells of turbot (Scophthalmus maximus)
Wang T, et al.
Frontiers in Endocrinology, 9 (2018)
Michal Bohdanowicz et al.
Molecular biology of the cell, 24(11), 1700-1712 (2013-04-12)
Macrophages and dendritic cells continuously survey their environment in search of foreign particles and soluble antigens. Such surveillance involves the ongoing extension of actin-rich protrusions and the consequent formation of phagosomes and macropinosomes. The signals inducing this constitutive cytoskeletal remodeling
Chi-Lun Chang et al.
The Journal of biological chemistry, 290(23), 14289-14301 (2015-04-19)
Phosphatidylinositol (PI) 4,5-bisphosphate (PIP2) at the plasma membrane (PM) constitutively controls many cellular functions, and its hydrolysis via receptor stimulation governs cell signaling. The PI transfer protein Nir2 is essential for replenishing PM PIP2 following receptor-induced hydrolysis, but key mechanistic

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