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Merck
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Documentos

W381918

Sigma-Aldrich

L-arginina

99%, FCC, FG

Sinónimos:

Ácido (S)-2-amino-5-guanidinopentanoico

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About This Item

Fórmula lineal:
H2NC(=NH)NH(CH2)3CH(NH2)CO2H
Número de CAS:
74-79-3
Peso molecular:
174.20
FEMA Number:
3819
Beilstein/REAXYS Number:
1725413
EC Number:
200-811-1
MDL number:
MFCD00002635
UNSPSC Code:
12164502
eCl@ss:
32160406
PubChem Substance ID:
24901894
Flavis number:
17.003
NACRES:
NA.21

biological source

synthetic

grade

FG

agency

meets purity specifications of JECFA

reg. compliance

EU Regulation 1334/2008 & 872/2012
FCC
FDA 21 CFR 172.320

assay

99%

form

powder or crystals

optical activity

[α]20/D +27°, c = 8 in 6 M HCl

mp

222 °C (dec.) (lit.)

application(s)

flavors and fragrances

documentation

see Safety & Documentation for available documents

food allergen

no known allergens

organoleptic

faint

SMILES string

N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1

InChI key

ODKSFYDXXFIFQN-BYPYZUCNSA-N

Gene Information

human ... NOS1(4842) , NOS2(4843)
rat ... Ppm1a(24666)

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Categorías relacionadas

General description

L-Arginine is an amino acid that plays a key role in many physiological processes such as tissue repair and reproduction. It is a key precursor for synthesizing nitric oxide in mammals. Due to these factors, the dietary supplementation with L-arginine may show a range of health benefits.

Application


  • Metabolomic approaches to dissect dysregulated metabolism in the progression of pre-diabetes to T2DM.: This study employs L-Arginine to examine metabolic changes during the transition from pre-diabetes to type 2 diabetes mellitus, offering new targets for early intervention (Ji et al., 2024 Jun). Link to the article.

  • Amino acid profile alteration in age-related atrial fibrillation.: Investigates the role of L-Arginine in cardiovascular aging, highlighting its potential in developing therapeutic strategies against atrial fibrillation associated with aging (Huang et al., 2024 Mar). Link to the article.

Biochem/physiol Actions

Sustrato de la óxido nítrico sintasa, que se convierte en citrulina y óxido nítrico (NO). Induce la liberación de insulina mediante un mecanismo dependiente del óxido nítrico.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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L-arginina monohydrochloride reagent grade, ≥98% (HPLC), powder

Sigma-Aldrich

A5131

L-arginina monohydrochloride

L-arginina monohydrochloride European Pharmacopoeia (EP) Reference Standard

A1271000

L-arginina monohydrochloride

L-arginina monohydrochloride British Pharmacopoeia (BP) Reference Standard

BP694

L-arginina monohydrochloride

Blood pressure and metabolic changes during dietary L-arginine supplementation in humans.
Siani A, et al.
American Journal of Hypertension, 13(5), 547-551 (2000)
L-Arginine Research Progress (2012)
Diane N Singhroy et al.
Retrovirology, 10, 73-73 (2013-07-23)
Protein arginine methyltransferase 6 (PRMT6) is a nuclear enzyme that methylates arginine residues on histones and transcription factors. In addition, PRMT6 inhibits HIV-1 replication in cell culture by directly methylating and interfering with the functions of several HIV-1 proteins, i.e.
Palaniraja Thandapani et al.
Molecular cell, 50(5), 613-623 (2013-06-12)
Motifs rich in arginines and glycines were recognized several decades ago to play functional roles and were termed glycine-arginine-rich (GAR) domains and/or RGG boxes. We review here the evolving functions of the RGG box along with several sequence variations that
Krishnan Suresh Kumar et al.
European journal of medicinal chemistry, 45(11), 5474-5479 (2010-08-21)
A new series of 3-(benzylideneamino)-2-phenylquinazoline-4(3H)-ones were prepared through Schiff base formation of 3-amino-2-phenyl quinazoline-4(3)H-one with various substituted carbonyl compounds. Their chemical structures were elucidated by spectral studies. Cytotoxicity and antiviral activity were evaluated against herpes simplex virus-1 (KOS), herpes simplex
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