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A77806

Sigma-Aldrich

4-Aminopyrazolo[3,4-d]pyrimidine

98%

Sinónimos:

1H-Pyrazolo[3,4-d]pyrimidine-4-ylamine, 4-Amino-1H-pyrazolo[3,4-d]pyrimidine

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About This Item

Fórmula empírica (notación de Hill):
C5H5N5
Número de CAS:
2380-63-4
Peso molecular:
135.13
EC Number:
219-174-6
MDL number:
MFCD00005688
UNSPSC Code:
12352100
PubChem Substance ID:
24891277
NACRES:
NA.22

assay

98%

form

powder

mp

>325 °C (lit.)

SMILES string

Nc1ncnc2[nH]ncc12

InChI

1S/C5H5N5/c6-4-3-1-9-10-5(3)8-2-7-4/h1-2H,(H3,6,7,8,9,10)

InChI key

LHCPRYRLDOSKHK-UHFFFAOYSA-N

Application

Decreases serum cholesterol markedly in rats.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
MKCD9262
07024DT
S27391
05030EM
S16577

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S Azhar et al.
Biochemistry, 23(20), 4533-4538 (1984-09-25)
These studies were done to examine the effect of gonadotropin on rat luteal 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase activity (the rate-limiting step in cholesterol biosynthesis) in ovaries of pregnant mare's serum gonadotropin (PMSG)-human chorionic gonadotropin (hCG) primed rats. Administration
M Bertolotti et al.
Journal of lipid research, 37(8), 1812-1822 (1996-08-01)
This study was performed to investigate the effects of 17 alpha-ethinyl estradiol, a potent hypocholesterolemic agent at pharmacological doses, on cholesterol balance in the liver and extrahepatic tissues of the rat in vivo. Female Sprague-Dawley rats were treated with 17
R F Aten et al.
Endocrinology, 135(2), 533-539 (1994-08-01)
Reactive oxygen species, such as superoxide, hydrogen peroxide, and lipid peroxides, impair luteal function. Vitamin E, a lipophilic antioxidant vitamin, provides a major avenue of protection by scavenging free radicals and terminating lipid peroxidation. We previously showed that ovarian vitamin
S Wu-Pong et al.
The Journal of investigative dermatology, 102(5), 799-802 (1994-05-01)
Barrier perturbation stimulates epidermal cholesterol synthesis, which plays an important role in restoring barrier function. In the present study, we examined whether changes in serum cholesterol levels or nutrition regulate epidermal cholesterol synthesis in hairless mice. Serum cholesterol levels were
J F Goodrum
Journal of neurochemistry, 60(4), 1564-1566 (1993-04-01)
Following a nerve crush, cholesterol from degenerating myelin is retained within the nerve and reutilized for new myelin synthesis during nerve regeneration, apparently via a lipoprotein-mediated process. Because at least some serum components have access to the endoneurium of injured
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