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910791

Sigma-Aldrich

Poly(ethylene glycol)-block-polyethyleneimine

PEG Mn 750, PEI Mn 15k

Sinónimos:

Linear poly(ethylene glycol)-block-polyethylenimine, PEG-b-PEI, PEG-PEI

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About This Item

Fórmula lineal:
CH3(C2H4O)m(C2H5N)nOH
UNSPSC Code:
12162002
NACRES:
NA.23

form

powder or solid

mol wt

PEG Mn 750
PEG Mw 750 Da
PEI Mn 15k
PEI Mw 10,000 Da

color

white to pale yellow

storage temp.

2-8°C

Categorías relacionadas

Application

Gene therapy using polymeric nonviral vectors promises considerable advances in the treatment of many genetic and acquired diseases due to the carrier safety and low immunogenicity profiles. Poly(ethyleneimine) is one of the most commonly used cationic polymers for gene delivery applications. Copolymers of PEI and hydrophilic poly(ethylene glycol) have been designed to provide a stealth-like shield around polymer/DNA complexes, reducing nonspecific interactions, inhibiting activation of the reticuloendothelial system, and prolonging the half-life of the complexes in the blood.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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B Brissault et al.
Biomacromolecules, 7(10), 2863-2870 (2006-10-10)
The study of ethyloxazoline/methyloxazoline (EtOXZ/MeOXZ) copolymerization, initiated by methyl tosylate (MeOTs), showed that (i) incorporation of MeOXZ units into random copolymer becomes effective over DP = 100 and (ii) propagation process proceeds with negligible transfer to monomer up to a
Dagmar Fischer et al.
Drug metabolism and disposition: the biological fate of chemicals, 32(9), 983-992 (2004-08-21)
The in vivo body distribution and the pharmacokinetics of a 20mer double-stranded nuclear factor kappaB decoy oligodeoxynucleotide (ODN) complexed with 25-kDa poly(ethylene imine) (PEI), low molecular weight 2.7-kDa PEI, and PEGylated PEI [bPEI(25k)-glPEG(550)(50)] after intravenous injection were studied in BALB/c
Pallab Banerjee et al.
Bioconjugate chemistry, 17(1), 125-131 (2006-01-19)
A block copolymer of a hyperbranched poly(ethylene glycol)-like core and linear polyethylenimine (HBP) was synthesized by a facile synthetic route that included (1) a single-step cationic copolymerization of diepoxy and polyhydroxyl monomers, (2) derivatization of hydroxyl groups of the core

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