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Merck

901376

Sigma-Aldrich

Polyester bis-MPA dendron

no. Surface Groups 8, 8 acetylene, 1 NHBoc (core), generation 3

Sinónimos:

PFd-G3-BOCNH-Acetylene, bis-MPA dendron

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About This Item

Fórmula empírica (notación de Hill):
C107H135NO53
Peso molecular:
2283.19
UNSPSC Code:
12162002
NACRES:
NA.23

Quality Level

form

solid

mol wt

generation 3

no. Surface Groups

8

color

white to off-white

storage temp.

−20°C

General description

  • Polymer architecture: Dendron
  • Generation: 3
  • Core functional group: Boc-protected amine
  • End Group Functionality: Alkyne
  • No. Surface Groups: 8
  • Calculated Mol. Wt.: 2283.21 g/mol
  • Boc : tert-Butyloxycarbonyl
  • bis-MPA : 2,2-Bis(hydroxymethyl)propionic acid
Polyester bis-MPA dendron (8 acetylene, 1 NHBoc (core), generation 3), a high generation dendron, is synthesized by using anhydride activated bis-MPA monomers via divergent growth. It has a large and exact number of reactive groups and has dual functionalization capacity that makes it useful as a high-value scaffold.

Application

Bis-MPA (or 2,2-Bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrons synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. These alkyne-functionalized dendrimers can be readily functionalized using either copper(I)-catalysed alkyne-azide cycloaddition (CuAAC), strain-promoted alkyne-azide cycloaddition (SPAAC), or thiol-yne click reactions. Additionally, the amine-functionalized core can be readily used in EDC or DCC coupling reactions (after Boc deprotection) with carbonyl-containing compounds to yield highly functionalized materials for a variety of biomedical applications.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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