900913

Tetrazine-PEG5-NHS ester

≥95%

• Sinónimos: Tz-PEG5-NHS
• Fórmula empírica (notación de Hill): C₂₇H₃₆N₆O₁₀
• Número de CAS: 1682653-80-0
• Peso molecular: 604.61
• MDL number: MFCD28505547
• UNSPSC Code: 12352108
• NACRES: NA.22

Propiedades

• Quality Level: 100
• assay: ≥95%
• form: powder or crystals
• reaction suitability: reaction type: click chemistry; reagent type: linker
• functional group: NHS ester
• storage temp.: −20°C
• SMILES string: O=C(NCC1=CC=C(C2=NN=CN=N2)C=C1)CCOCCOCCOCCOCCOCCC(ON3C(CCC3=O)=O)=O

Descripción

General description

Tetrazine-PEG5-NHS ester has an N-hydroxysuccinimide (NHS) ester that can be reacted with primary amines and tetrazine, which is reactive to trans-cyclooctenes. Hydrogen substituted tetrazines demonstrate exceptionally fast kinetics, generally at least 10-fold faster compared to methyl substituted tetrazines. The aqueous solubility of this reagent is substantially enhanced by a hydrophilic polyethylene glycol (PEG) spacer arm.

Application

Tetrazine-PEG5-NHS ester (Tz-PEG₅-NHS) can be used in click chemistry applications such as the preparation of chitosan-polyacrylamide microspheres utilizing selective tetrazine-trans-cyclooctene (Tz-TCO) ligation and the construction of copper-64 radiolabeled antibody by the click reaction.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable