222569

Fomepizole

99%

• Sinónimos: 4-Methylpyrazole
• Fórmula empírica (notación de Hill): C₄H₆N₂
• Número de CAS: 7554-65-6
• Peso molecular: 82.10
• Beilstein/REAXYS Number: 105204
• EC Number: 231-445-0
• MDL number: MFCD00005245
• UNSPSC Code: 12352100
• PubChem Substance ID: 24853343
• NACRES: NA.22

Propiedades

• assay: 99%
• refractive index: n20/D 1.495 (lit.)
• bp: 99-100 °C/6 mmHg (lit.)
• solubility: alcohol: soluble(lit.); water: soluble(lit.)
• density: 0.993 g/mL at 25 °C (lit.)
• SMILES string: Cc1cn[nH]c1
• InChI: 1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6)
• InChI key: RIKMMFOAQPJVMX-UHFFFAOYSA-N
• Gene Information: human ... ADH1A(124) , ADH1B(125) , ADH1C(126)

Descripción

General description

4-Methylpyrazole inhibits CYP2E1 activity. It also acts as alcohol dehydrogenase inhibitor.

Application

Fomepizole (4-Methylpyrazole) can be used as:

• A reactant to prepare 4-methyl-1-phenyl-1H-pyrazole by reacting with bromobenzene via N-arylation using a copper catalyst.
• A starting material for the synthesis of 4-methyl-3(5)-nitropyrazole by nitration.
• A ligand in the preparation of gallium(III) complex of 4-methylpyrazole as potential antitumor and antiviral agent.

Useful as an antidote in methanol and ethylene glycol poisoning.

Biochem/physiol Actions

Alcohol dehydrogenase inhibitor

Alcohol dehydrogenase inhibitor.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319,H335
• pcodes: P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: 204.8 °F - closed cup
• flash_point_c: 96 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter