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222526

Sigma-Aldrich

3-Methylxanthine

98%

Sinónimos:

2,6-Dihydroxy-3-methylpurine

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About This Item

Fórmula empírica (notación de Hill):
C6H6N4O2
Número de CAS:
1076-22-8
Peso molecular:
166.14
Beilstein/REAXYS Number:
180944
EC Number:
214-058-1
MDL number:
MFCD00005580
UNSPSC Code:
12352005
PubChem Substance ID:
24853339
NACRES:
NA.22

assay

98%

mp

>300 °C (lit.)

SMILES string

CN1C(=O)NC(=O)c2[nH]cnc12

InChI

1S/C6H6N4O2/c1-10-4-3(7-2-8-4)5(11)9-6(10)12/h2H,1H3,(H,7,8)(H,9,11,12)

InChI key

GMSNIKWWOQHZGF-UHFFFAOYSA-N

Gene Information

rat ... Adora1(29290) , Adora2a(25369)

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General description

3-Methylxanthine, a metabolite of theophylline, was quantitated in rat plasma by a sensitive LC-MS/MS method.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
MKCN8804
MKCM5002
MKCJ8406
MKBZ5376V
MKBT9092V

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1,7-Dimethylxanthine ~98%, solid

Sigma-Aldrich

D5385

1,7-Dimethylxanthine

M Sarkar et al.
Antimicrobial agents and chemotherapy, 34(4), 594-599 (1990-04-01)
Some quinolone antibiotics cause increases in levels of theophylline in plasma that lead to serious adverse effects. We investigated the mechanism of this interaction by developing an in vitro system of human liver microsomes. Theophylline (1,3-dimethylxanthine) was incubated with human
G A Soukup et al.
Journal of molecular biology, 298(4), 623-632 (2000-05-02)
In a continuing effort to explore structural and functional dynamics in RNA catalysis, we have created a series of allosteric hammerhead ribozymes that are activated by theophylline. Representative ribozymes exhibit greater than 3000-fold activation upon effector-binding and cleave with maximum
H Konishi et al.
European journal of clinical pharmacology, 46(4), 309-312 (1994-01-01)
The effect of fluconazole, an antimycotic that inhibits cytochrome P-450-mediated drug metabolism, on theophylline kinetics and the production of its metabolites were compared with those of enoxacin in 5 healthy subjects. All subjects received a single oral dose of 240
Sandrine Derkenne et al.
Pharmacogenetics and genomics, 15(7), 503-511 (2005-06-23)
Pharmacokinetics of theophylline was investigated in Cyp1(+/+) wild-type mice, Cyp1a1(-/-) and Cyp1a2(-/-) knockout mice, and humanized hCYP1A1_1A2 mice lacking either the mouse Cyp1a1 or Cyp1a2 gene. Animals received a single dose of theophylline (8 mg/kg i.p.), either alone or pretreated
Sang Won Lee et al.
Biochemistry, 49(13), 2943-2951 (2010-03-11)
RNAs often exhibit a high degree of conformational dynamics and heterogeneity, leading to a rugged energy landscape. However, the roles of conformational heterogeneity and rapid dynamics in molecular recognition or RNA function have not been extensively elucidated. Ultrafast time-resolved fluorescence
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Artículos

HPLC Analysis of Xanthines on Purospher® STAR RP-18 endcapped

Xanthine is a purine base found in most human body tissues and fluids as well as in other organisms. Methylated xanthines (methylxanthines), which include caffeine, paraxanthine, theobromine, and theophylline, commonly used for their effects as mild stiµlants and as bronchodilators, notably in the treatment of asthma symptoms. This application shows the efficient separation of several common xanthines and may be applied their analysis in any number of desired matrices.

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