183733
4′-(Imidazol-1-yl)acetophenone
96%
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About This Item
Fórmula empírica (notación de Hill):
C11H10N2O
Número de CAS:
Peso molecular:
186.21
EC Number:
MDL number:
UNSPSC Code:
12352005
PubChem Substance ID:
NACRES:
NA.22
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Quality Level
assay
96%
form
solid
mp
108-110 °C (lit.)
functional group
ketone
SMILES string
CC(=O)c1ccc(cc1)-n2ccnc2
InChI
1S/C11H10N2O/c1-9(14)10-2-4-11(5-3-10)13-7-6-12-8-13/h2-8H,1H3
InChI key
GAIQQJIMVVUTQN-UHFFFAOYSA-N
Categorías relacionadas
General description
4′-(Imidazol-1-yl)acetophenone is a selective thromboxane synthesis inhibitor.
Application
4′-(Imidazol-1-yl)acetophenone was used in the synthesis of (R)-(+)-4′-(imidozol-1-yl)-phenyl ethanol using spiroborate catalyst.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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H D Uderman et al.
Prostaglandins, 24(2), 237-244 (1982-08-01)
The compound 4'-(imidazol-1-yl) acetophenone was demonstrated to be a selective thromboxane (Tx) synthetase inhibitor in spontaneously hypertensive rats (SHR). Serum TxB2 concentrations (from clotted blood) were suppressed by 89.1% (p less than 0.001) and 41.2% (p less than 0.01) at
W D Watkins et al.
Prostaglandins, 23(3), 273-285 (1982-03-01)
We assessed the effect of a specific thromboxane synthetase inhibitor (an imidazole derivative) on pulmonary hemodynamics and the concentrations of TxB2 (TxA2), 6-keto-PGF1 alpha (PGI2), and PGF2 in pulmonary lymph and transpulmonary blood samples following intravenous administration of E. coli
P A Craven et al.
The Journal of laboratory and clinical medicine, 116(4), 469-478 (1990-10-01)
Thromboxane contributes to the regulation of glomerular hemodynamics in experimental models of diabetes and has been implicated as mediator in some models of glomerular injury. In the present study we examined urinary albumin, protein, and thromboxane B2 (TXB2) excretion during
Viatcheslav Stepanenko et al.
Tetrahedron, asymmetry, 18(23), 2738-2745 (2007-11-26)
The effectiveness of several spiroborate ester catalysts was investigated in the asymmetric borane reduction of 2-, 3-, 4-acetylpyridines under different reaction conditions. Highly enantiomerically enriched 1-(2-, 3- and 4-pyridyl)ethanols and 1-(heterocyclic)ethanols were obtained using 1 to 10% catalytic loads of
J Triscari et al.
International journal of obesity, 11 Suppl 3, 43-51 (1987-01-01)
A selective inhibitor of thromboxane synthase, Ro 22-3581 has been shown to be a useful tool for investigating the relationship between hyperinsulinemia and obesity. These studies have established that the pharmacologic normalization of the hyperinsulinemia associated with elevated weights in
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