TRAF2
TNF receptor-associated factor 2
Sinónimos:
MGC:45012, TRAP, TRAP3
Especie:
Human TRAF2 (7186), Mouse Traf2 (22030), Rat Traf2 (311786), cow TRAF2 (512355), domestic guinea pig Traf2 (100733145), naked mole-rat Traf2 (101705156), chicken TRAF2 (417287), domestic cat TRAF2 (101096363), dog TRAF2 (480673)
ID UniProtKB:
ID del gen:
- Human(7186) Summary: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq, Jul 2008]
- Mouse(22030) TNF receptor-associated factor 2
- Rat(311786) Tnf receptor-associated factor 2
- cow(512355) TNF receptor-associated factor 2
- domestic guinea pig(100733145) TNF receptor-associated factor 2
- naked mole-rat(101705156) TNF receptor-associated factor 2
- chicken(417287) TNF receptor-associated factor 2
- domestic cat(101096363) TNF receptor-associated factor 2
- dog(480673) TNF receptor-associated factor 2
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-[KD Validated] TRAF2 Antibody, clone 3S2A8, Rabbit Monoclonal, ,
Reactividad de especies
human, rat
Aplicación
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-TRAF2 Antibody, clone 3F11 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
bovine, canine, horse, human, monkey, mouse, porcine
Aplicación
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot