MDM2
MDM2 oncogene, E3 ubiquitin protein ligase
Sinónimos:
ACTFS, HDMX, hdm2
Especie:
Human MDM2 (4193), Mouse Mdm2 (17246), Rat Mdm2 (314856), Zebrafish mdm2 (30637), dog MDM2 (403693), domestic cat MDM2 (493939), cow MDM2 (540378), Horse MDM2 (100033891), chicken MDM2 (395609), domestic guinea pig Mdm2 (100724684) ...Más
ID UniProtKB:
ID del gen:
- Human(4193) Summary: This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
- Mouse(17246) transformed mouse 3T3 cell double minute 2
- Rat(314856) p53 E3 ubiquitin protein ligase
- Zebrafish(30637) transformed 3T3 cell double minute 2 homolog (mouse)
- dog(403693) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
- domestic cat(493939) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
- cow(540378) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
- Horse(100033891) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
- chicken(395609) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
- domestic guinea pig(100724684) MDM2 oncogene, E3 ubiquitin protein ligase
- naked mole-rat(101724821) MDM2 oncogene, E3 ubiquitin protein ligase
- sheep(101104979) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anticuerpo anti-MDM2, clon IF2, clone IF2, from mouse,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot
western blot
Anti-MDM2 (Ab-2) Mouse mAb (2A10), liquid, clone 2A10, Calbiochem®,
Reactividad de especies
human
Aplicación
Anti-MDM2 Antibody, clone IF2, Alexa Fluor™ 488 Conjugate, clone IF2, from mouse, ALEXA FLUOR™ 488,
Reactividad de especies
human
Aplicación
immunocytochemistry
Anti-MDM2 Antibody, clone 2A10, clone 2A10, from mouse,
Reactividad de especies
human
Aplicación
immunoprecipitation (IP)
western blot
western blot
Anti-MDM2 Antibody, clone IF2, Alexa Fluor™ 555 Conjugate, clone IF2, from mouse, ALEXA FLUOR™ 555,
Reactividad de especies
human
Aplicación
immunocytochemistry
Proteins
Referencia del producto
Descripción
Especie
MDM2 human, recombinant, expressed in E. coli, buffered aqueous glycerol solution, ≥75% (SDS-PAGE),
Especie
human