GSTA4
glutathione S-transferase alpha 4
Sinónimos:
GSTA4-4, GTA4
Especie:
Human GSTA4 (2941), Mouse Gsta4 (14860), Rat Gsta4 (300850), domestic guinea pig Gsta4 (100732190), naked mole-rat Gsta4 (101714626), cow GSTA4 (533917), Horse GSTA4 (100056597), dog GSTA4 (474939)
ID UniProtKB:
ID del gen:
- Human(2941) Summary: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis. [provided by RefSeq, Jul 2008]
- Mouse(14860) glutathione S-transferase, alpha 4
- Rat(300850) glutathione S-transferase alpha 4
- domestic guinea pig(100732190) glutathione S-transferase alpha 4
- naked mole-rat(101714626) glutathione S-transferase alpha 4
- cow(533917) glutathione S-transferase alpha 4
- Horse(100056597) glutathione S-transferase alpha 4
- dog(474939) glutathione S-transferase alpha 4
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