SRP6196

IL-4Rα human

recombinant, expressed in HEK 293 cells, ≥98% (SDS-PAGE)

• Synonym(s): CD124, IL-4 receptor alpha
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• biological source: human
• recombinant: expressed in HEK 293 cells
• Assay: ≥98% (SDS-PAGE)
• form: lyophilized powder
• mol wt: ~24 kDa
• packaging: pkg of 10 and 50 μg
• UniProt accession no.: P24394
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... IL4RA(3566)

Description

General description

IL-4 can signal through type I and type II receptor complexes, which share a common gamma chain (γc). The type I receptor contains in addition to the γc an IL-4Rα subunit, where as the type II receptor contains the IL-13Rα. The secreted extracellular domain of IL-4Rα, called sIL-4Rα, binds IL-4 and antagonizes its activity. It plays an important role in regulating the differentiation of naïve CD4+ T cells and class switching to IgG1 and IgE. Recombinant human sIL-4Rα is a 209 amino acid protein which corresponds to the entire extracellular domain of IL-4Rα.

Physical form

Sterile filtered through a 0.2 micron filter. Lyophilized from 1x PBS pH 7.0.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to - 80°C.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable