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SML1554

Sigma-Aldrich

S3QEL 2

Synonym(s):

1-(3,4-Dimethylphenyl)-N,N-dipropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

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10 ML
867,00 NZD
125 ML
10.090,00 NZD

867,00 NZD

Estimated to ship on04 de mayo de 2025

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10 ML
867,00 NZD
125 ML
10.090,00 NZD

About This Item

Empirical Formula (Hill Notation):
C19H25N5
CAS Number:
890888-12-7
Molecular Weight:
323.44
UNSPSC Code:
12352200
NACRES:
NA.77

867,00 NZD

Estimated to ship on04 de mayo de 2025

Request a Bulk Order

form

powder

Quality Level

100

color

white to beige

solubility

DMSO: 5 mg/mL, clear

storage temp.

−20°C

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This Item
SML1435SML0333SML0929
S3QEL 2

SML1554

S3QEL 2

SPP86 ≥98% (HPLC)

SML1435

SPP86

NVP-BHG712 ≥98% (HPLC)

SML0333

NVP-BHG712

HS38 ≥95% (HPLC)

SML0929

HS38

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

DMSO: 5 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 5 mg/mL, clear (warmed)

color

white to beige

color

white to beige

color

white to beige

color

white to beige

Biochem/physiol Actions

S3QEL 2 is a selective inhibitor of superoxide production from the outer Q-binding site of mitochondrial respiratory complex site III (IIIQo) without altering oxidative phosphorylation.
S3QEL 2 is a selective inhibitor of superoxide production from the outer Q-binding site of mitochondrial respiratory complex site III (IIIQo) without altering oxidative phosphorylation. Site IIIQo is the primary source of mitochondrial reactive oxygen species (ROS) and has been implicated in a broad range of ROS-mediated signaling and pathology. S3QEL 2 lowered HIF-1α induction, protected against ROS-induced, JNK-mediated cell stress in pancreatic beta-cells, and decreased the oxidative stress-induced apoptosis that limits the yield of functional β-cells from intact islets.
S3QEL 2, a cell permeable substituted allopurinol, is also known as 1-(3,4-Dimethylphenyl)-N,N-dipropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine.[1]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number
    046M4729V

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    The Inhibitor Index: A Desk Reference on Enzyme Inhibitors, Receptor Antagonists, Drugs, Toxins, Poisons, Biologics, and Therapeutic Leads (2017)
    Takujiro Homma et al.
    Archives of biochemistry and biophysics, 700, 108775-108775 (2021-01-26)
    Ferroptosis is a type of iron-dependent, non-apoptotic cell death, which is typically induced by cysteine starvation or by the inhibition of glutathione peroxidase 4 (GPX4) activity with the accompanying elevation in lipid peroxidation product levels. Despite the central role of
    Remi Hatinguais et al.
    Frontiers in immunology, 12, 641495-641495 (2021-04-13)
    Reactive Oxygen Species (ROS) are highly reactive molecules that can induce oxidative stress. For instance, the oxidative burst of immune cells is well known for its ability to inhibit the growth of invading pathogens. However, ROS also mediate redox signalling

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