SML1152

GSK137647A

≥98% (HPLC)

• Synonym(s): 4-Methoxy-N-(2,4,6-trimethylphenyl)-benzenesulfonamide, N-Mesityl-4-methoxybenzenesulfonamide
• Empirical Formula (Hill Notation): C₁₆H₁₉NO₃S
• CAS Number: 349085-82-1
• Molecular Weight: 305.39
• MDL number: MFCD02007969
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825685
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CC1=C(NS(C2=CC=C(OC)C=C2)(=O)=O)C(C)=CC(C)=C1
• InChI: 1S/C16H19NO3S/c1-11-9-12(2)16(13(3)10-11)17-21(18,19)15-7-5-14(20-4)6-8-15/h5-10,17H,1-4H3
• InChI key: FQUAFMNPXPXOJE-UHFFFAOYSA-N

Description

Biochem/physiol Actions

GSK137647A is a selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), which is involved in long-chain fatty acid stimulated GLP-1 secretion and has been implicated in glucose homeostasis, adiposity, and regulation of the anti-inflammatory response. GSK137647A has pEC₅₀ values of 6.3, 6.2, and 6.1 for human, mouse and rat FFA4, and pEC₅₀ values < 4.5 for all three species for FFA1, FFA2, and FFA3.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable