Skip to Content
Merck
All Photos(2)

Key Documents

SAB4502982

Sigma-Aldrich

Anti-TNFA antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Cachectin, TNF-α, TNF-a, Tumor necrosis factor, Tumor necrosis factor ligand superfamily member 2

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

MDL number:
MFCD00162116
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 25 kDa

species reactivity

mouse, human, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100

NCBI accession no.

P01375

UniProt accession no.

P01375

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TNF(7124)

General description

Anti-TNFA Antibody detects endogenous levels of total TNFA protein.
The TNFA (tumor necrosis factor α) gene is mapped to human chromosome 6p21.33 and codes for a pro-inflammatory cytokine.

Immunogen

The antiserum was produced against synthesized peptide derived from human TNFA.

Immunogen Range: 141-190

Biochem/physiol Actions

The TNFA (tumor necrosis factor α) gene is significantly associated with the regulation of innate and adaptive immune responses. Polymorphism of TNFA gene is known to cause acute motor axonal neuropathy. The cytokine release and gene action is associated with epithelial cells, myeloid cells, endothelial, as well as tumor cells. Tumor cells are known to release TNFA, specifically in response to chemotherapy

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Localization of the genes for tumor necrosis factor and lympotoxin between the HLA class field inversion gel electrophoresis.
J. Ragoussis
Immunogenetics, 27, 66-69 (1988)
Syndecan-4 in intervertebral disc and cartilage: Saint or Synner?
Binch ALA
Matrix Biology, 52-54, 355-362 (2016)
Hung-Jen Wang et al.
International journal of molecular sciences, 20(19) (2019-09-29)
The effect of low energy shock wave (LESW) therapy on the changes of inflammatory molecules and pain reaction was studied in a capsaicin (10 mM, 0.1 cc) induced prostatitis model in rats. Intraprostatic capsaicin injection induced a pain reaction, including
Inflammatory cytokine production in tumor cells upon chemotherapy drug exposure or upon selection for drug resistance
Edwardson D.W
PLoS ONE, 12(9), 1-32 (2017)
Roosmarijn E Vandenbroucke et al.
EMBO molecular medicine, 5(7), 1000-1016 (2013-06-01)
Several pathological processes, such as sepsis and inflammatory bowel disease (IBD), are associated with impairment of intestinal epithelial barrier. Here, we investigated the role of matrix metalloproteinase MMP13 in these diseases. We observed that MMP13(-/-) mice display a strong protection
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service